Gene Symbol | S1PR3 |
---|---|
Entrez Gene | 1903 |
Alt Symbol | EDG-3, EDG3, LPB3, S1P3 |
Species | Human |
Gene Type | protein-coding |
Description | sphingosine-1-phosphate receptor 3 |
Other Description | G protein-coupled receptor, endothelial differentiation gene-3|S1P receptor 3|S1P receptor EDG3|S1P receptor Edg-3|endothelial differentiation G-protein coupled receptor 3|endothelial differentiation, sphingolipid G-protein-coupled receptor, 3|sphingosine 1-phosphate receptor 3|sphingosine 1-phosphate receptor Edg-3 |
Swissprots | Q99500 Q5SQD8 Q7Z5I2 |
Accessions | AAP84353 CAA58744 EAW62758 Q99500 AF022139 AAC51906 AK312798 BAG35658 AL832194 BC060827 AAH60827 BC069579 AAH69579 BM990167 DA722994 DR763542 NM_005226 NP_005217 |
Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. {ECO:0000269|PubMed:10617617}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. |
Top Pathways | Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction |
EDG-3 CRISPR/Cas9 KO Plasmid (h) - sc-401366 from Santa Cruz Biotechnology
|
||||||||
EDG-3 HDR Plasmid (h) - sc-401366-HDR from Santa Cruz Biotechnology
|
||||||||
EDG-3 Double Nickase Plasmid (h) - sc-401366-NIC from Santa Cruz Biotechnology
|
||||||||
EDG-3 Double Nickase Plasmid (h2) - sc-401366-NIC-2 from Santa Cruz Biotechnology
|
||||||||
EDG-3 CRISPR Activation Plasmid (h) - sc-401366-ACT from Santa Cruz Biotechnology
|
||||||||
EDG-3 CRISPR Activation Plasmid (h2) - sc-401366-ACT-2 from Santa Cruz Biotechnology
|
||||||||
EDG-3 Lentiviral Activation Particles (h) - sc-401366-LAC from Santa Cruz Biotechnology
|
||||||||
EDG-3 Lentiviral Activation Particles (h2) - sc-401366-LAC-2 from Santa Cruz Biotechnology
|
||||||||
EDG-3 siRNA (h) - sc-35261 from Santa Cruz Biotechnology
|
||||||||
EDG-3 shRNA Plasmid (h) - sc-35261-SH from Santa Cruz Biotechnology
|
||||||||
EDG-3 shRNA (h) Lentiviral Particles - sc-35261-V from Santa Cruz Biotechnology
|
||||||||
S1P3/EDG-3 RNAi - H00001903-R02 from Novus Biologicals
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18803 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18803 from Sigma-Aldrich
|
||||||||
S1PR3 siRNA (Human) - CRH1324 from Cohesion Biosciences
|
||||||||
S1PR3 - MBS8216374 from MyBioSource
|
||||||||
EDG-3 CRISPR/Cas9 KO Plasmid (h2) - sc-401366-KO-2 from Santa Cruz Biotechnology
|
||||||||
EDG-3 HDR Plasmid (h2) - sc-401366-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human S1PR3 (NM_005226.3) - SHH401348 from Creative biogene
|
||||||||
Human S1PR3 siRNA - orb261826 from Biorbyt
|
||||||||
S1PR3 shRNA Plasmid (Human) - CHH1324 from Cohesion Biosciences
|
||||||||
S1PR3 miRNA 3'UTR clone - MiUTR4H-TG07750 from Creative biogene
|