| Gene Symbol |
ST3GAL6
|
| Entrez Gene |
10402
|
| Alt Symbol |
SIAT10, ST3GALVI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
|
| Other Description |
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI|alpha2,3-sialyltransferase ST3Gal VI|sialyltransferase 10 (alpha-2,3-sialyltransferase VI)|type 2 lactosamine alpha-2,3-sialyltransferase
|
| Swissprots |
F8W6U0 D3DN39 B2RCH2 Q9Y274 B3KMI1
|
| Accessions |
CAS91693 CBX32761 CBX46694 EAW79849 EAW79850 EAW79851 EAW79852 EAW79853 Q9Y274 AB022918 BAA77609 AF119391 AAD39131 AK001922 BAG50993 AK315111 BAG37569 AL539506 BC001266 BC012092 BC023312 AAH23312 CB960395 DB036799 HY123342 XM_005247067 XP_005247124 XM_005247069 XP_005247126 XM_005247070 XP_005247127 XM_005247071 XP_005247128 XM_005247072 XP_005247129 XM_006713474 XP_006713537 XM_006713476 XP_006713539 XM_011512335 XP_011510637 XM_011512336 XP_011510638 NM_001271142 NP_001258071 NM_001271145 NP_001258074 NM_001271146 NP_001258075 NM_001271147 NP_001258076 NM_001271148 NP_001258077 NM_006100 NP_006091
|
| Function |
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Glycosphingolipid biosynthesis - lacto and neolacto series
|