Gene Symbol | ST3GAL6 |
---|---|
Entrez Gene | 10402 |
Alt Symbol | SIAT10, ST3GALVI |
Species | Human |
Gene Type | protein-coding |
Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
Other Description | CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI|alpha2,3-sialyltransferase ST3Gal VI|sialyltransferase 10 (alpha-2,3-sialyltransferase VI)|type 2 lactosamine alpha-2,3-sialyltransferase |
Swissprots | F8W6U0 D3DN39 B2RCH2 Q9Y274 B3KMI1 |
Accessions | CAS91693 CBX32761 CBX46694 EAW79849 EAW79850 EAW79851 EAW79852 EAW79853 Q9Y274 AB022918 BAA77609 AF119391 AAD39131 AK001922 BAG50993 AK315111 BAG37569 AL539506 BC001266 BC012092 BC023312 AAH23312 CB960395 DB036799 HY123342 XM_005247067 XP_005247124 XM_005247069 XP_005247126 XM_005247070 XP_005247127 XM_005247071 XP_005247128 XM_005247072 XP_005247129 XM_006713474 XP_006713537 XM_006713476 XP_006713539 XM_011512335 XP_011510637 XM_011512336 XP_011510638 NM_001271142 NP_001258071 NM_001271145 NP_001258074 NM_001271146 NP_001258075 NM_001271147 NP_001258076 NM_001271148 NP_001258077 NM_006100 NP_006091 |
Function | Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |
Sialyltransferase 10 CRISPR/Cas9 KO Plasmid (h) - sc-418472 from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 HDR Plasmid (h) - sc-418472-HDR from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 Double Nickase Plasmid (h) - sc-418472-NIC from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 Double Nickase Plasmid (h2) - sc-418472-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 CRISPR Activation Plasmid (h) - sc-418472-ACT from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 CRISPR Activation Plasmid (h2) - sc-418472-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 Lentiviral Activation Particles (h) - sc-418472-LAC from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 Lentiviral Activation Particles (h2) - sc-418472-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 siRNA (h) - sc-76495 from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 shRNA Plasmid (h) - sc-76495-SH from Santa Cruz Biotechnology
|
||||||||
Sialyltransferase 10 shRNA (h) Lentiviral Particles - sc-76495-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU010221 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN20658 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20658 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR05751 from Sigma-Aldrich
|
||||||||
ST3GAL6 siRNA (Human) - CRH7051 from Cohesion Biosciences
|
||||||||
ST3GAL6 - MBS8204102 from MyBioSource
|
||||||||
shRNA set against Human ST3GAL6 (NM_006100.3) - SHH418860 from Creative biogene
|
||||||||
Human ST3GAL6 siRNA - orb267553 from Biorbyt
|
||||||||
ST3GAL6 shRNA Plasmid (Human) - CHH7051 from Cohesion Biosciences
|
||||||||
ST3GAL6 miRNA 3'UTR clone - MiUTR3H-09008 from Creative biogene
|