| Gene Symbol |
ULK1
|
| Entrez Gene |
8408
|
| Alt Symbol |
ATG1, ATG1A, UNC51, Unc51.1, hATG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-51 like autophagy activating kinase 1
|
| Other Description |
ATG1 autophagy related 1 homolog|autophagy-related protein 1 homolog|serine/threonine-protein kinase ULK1
|
| Swissprots |
O75385 Q9UQ28
|
| Accessions |
CBX47626 EAW98529 O75385 AB018265 BAA34442 AF045458 AAC32326 AK095774 AK128333 BC111603 AAI11604 BI822269 BU729635 CF131673 XM_011538798 XP_011537100 XM_011538799 XP_011537101 XR_944753 NM_003565 NP_003556
|
| Function |
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
|
| Top Pathways |
AMPK signaling pathway, Regulation of autophagy, mTOR signaling pathway
|
![Western Blot: ULK1 Overexpression Lysate (Adult Normal) [NBL1-17607] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ULK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5852_ULK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17607-img0002.jpg)