ULK1

Gene Symbol	ULK1
Entrez Gene	8408
Alt Symbol	ATG1, ATG1A, UNC51, Unc51.1, hATG1
Species	Human
Gene Type	protein-coding
Description	unc-51 like autophagy activating kinase 1
Other Description	ATG1 autophagy related 1 homolog|autophagy-related protein 1 homolog|serine/threonine-protein kinase ULK1
Swissprots	O75385 Q9UQ28
Accessions	CBX47626 EAW98529 O75385 AB018265 BAA34442 AF045458 AAC32326 AK095774 AK128333 BC111603 AAI11604 BI822269 BU729635 CF131673 XM_011538798 XP_011537100 XM_011538799 XP_011537101 XR_944753 NM_003565 NP_003556
Function	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Top Pathways	AMPK signaling pathway, Regulation of autophagy, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ULK1 ORF clone(NM_003565.2) - CDCL186686 from Creative Biomart Species Human Accession NM_003565.2

Human ULK1 ORF Clone(NM_003565.2) - CDCL180523 from Creative Biomart Species Human Accession NM_003565.2

Human ULK1 ORF Clone(NM_003565.2) - CDCL180524 from Creative Biomart Species Human Accession NM_003565.2

human ULK1 ORF clone - CDCH098144 from Creative Biomart Species Human Accession NM_003565

human ULK1 ORF clone - CDCH098145 from Creative Biomart Species Human Accession NM_003565

human ULK1 ORF clone - CDCH098146 from Creative Biomart Species Human Accession NM_003565

human ULK1 ORF clone - CDCH098147 from Creative Biomart Species Human Accession NM_003565

Human ULK1 Gene ORF cDNA clone in cloning vector - HG12031-G from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12031-NY from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12031-NF from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-His tag - HG12031-NH from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12031-CF from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12031-NM from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12031-CM from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-His tag - HG12031-CH from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12031-ACG from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid - HG12031-UT from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12031-CY from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12031-ANG from Sino Biological Species Human

Human ULK1 ORF clone(NM_003565.2) - CDCL186686 from Creative biogene Species Human

Human ULK1 gene - orb92801 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12031-ACR from Sino Biological Species Human

Human ULK1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12031-ANR from Sino Biological Species Human

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