ULK1

Gene Symbol	ULK1
Entrez Gene	8408
Alt Symbol	ATG1, ATG1A, UNC51, Unc51.1, hATG1
Species	Human
Gene Type	protein-coding
Description	unc-51 like autophagy activating kinase 1
Other Description	ATG1 autophagy related 1 homolog|autophagy-related protein 1 homolog|serine/threonine-protein kinase ULK1
Swissprots	O75385 Q9UQ28
Accessions	CBX47626 EAW98529 O75385 AB018265 BAA34442 AF045458 AAC32326 AK095774 AK128333 BC111603 AAI11604 BI822269 BU729635 CF131673 XM_011538798 XP_011537100 XM_011538799 XP_011537101 XR_944753 NM_003565 NP_003556
Function	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:21795849}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Top Pathways	AMPK signaling pathway, Regulation of autophagy, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ULK1 protein fragment - ab125656 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human ULK1 full length protein - ab152865 from Abcam Category Protein Source Wheat germ Species Human

Human ULK1 full length protein - ab95322 from Abcam Category Protein Source HEK 293 cells Species Human

Human ULK1 protein fragment - ab152866 from Abcam Category Protein Source Wheat germ Species Human

ULK1 Antibody Blocking Peptide - LS-E6490 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E6500 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E19514 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E7551 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E7553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E7552 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK1 Antibody Blocking Peptide - LS-E31435 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ULK1 Antibody Blocking Peptide - LS-E9498 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ULK1 Protein - H00008408-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human ULK1 Protein - H00008408-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ULK1-Antibody-Center-S317-Blocking-Peptide - BP19250c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK1-Antibody-Center-S556-Blocking-Peptide - BP19265c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-ULK1S556-Antibody-Blocking-peptide - BP3805a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-ULK1S556-Antibody-Blocking-peptide - BP3804a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-ULK1S317-Antibody-Blocking-peptide - BP3803a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

APG1-ULK1-Antibody-Center-Blocking-Peptide - BP8104d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG1-ULK1-Antibody-Center-Blocking-Peptide - BP8104c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG1-ULK1-Antibody-Center-Blocking-peptide - BP8104b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APG1-ULK1-Antibody-N-term-Blocking-Peptide - BP8104a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK1 / ATG1 - H00008408-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ULK1 / ATG1 - H00008408-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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