SNCA

Gene Symbol	SNCA
Entrez Gene	6622
Alt Symbol	NACP, PARK1, PARK4, PD1
Species	Human
Gene Type	protein-coding
Description	synuclein, alpha (non A4 component of amyloid precursor)
Other Description	alpha-synuclein|non A-beta component of AD amyloid|synuclein alpha-140
Swissprots	P37840 Q6IAU6 Q13701 A8K2A4 Q4JHI3
Accessions	AAC02114 AAG30302 AAG30303 AAS57868 AAS83394 AAY40956 AAY88735 CAS01777 CAS01781 EAX06035 EAX06036 P37840 AI815523 AK290169 BAF82858 AY049786 AAL15443 BC013293 AAH13293 BC108275 AAI08276 CR457058 CAG33339 CR541653 CAG46454 CR736451 D31839 BAA06625 DA391115 DQ892564 ABM83490 EU176705 ABW03506 HQ830267 AEG20815 HQ830268 AEG20816 HQ830269 AEG20817 JN709859 AFA25669 JN709860 AFA25670 JN709861 AFA25671 JN709862 AFA25672 JN709863 AFA25673 JN709864 AFA25674 JN709865 AFA25675 JN709866 AFA25676 JN709867 AFA25677 JN709868 AFA25678 JN709869 AFA25679 L08850 AAA16117 L36674 AAA98493 L36675 AAA98487 XM_011532203 XP_011530505 XM_011532204 XP_011530506 XM_011532205 XP_011530507 XM_011532206 XP_011530508 XM_011532207 XP_011530509 XM_011532208 XP_011530510 NM_000345 NP_000336 NM_001146054 NP_001139526 NM_001146055 NP_001139527 NM_007308 NP_009292
Function	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular Location	Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat SNCA / Alpha-Synuclein ELISA Kit (Cell-Based ELISA) - LS-F2342 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 15.63-1000 pg/ml

Human SNCA / Alpha-Synuclein ELISA Kit (Sandwich ELISA) - LS-F4486 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 15.63-1000 pg/ml

Mouse SNCA / Alpha-Synuclein ELISA Kit (Sandwich ELISA) - LS-F6284 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 78 pg/ml Range 15.63-1000 pg/ml

Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Ser129) Cell-Based ELISA Kit - LS-F1227 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Tyr133) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1634 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 15.63-1000 pg/ml

Mouse/Human/Rat Phospho-SNCA / Alpha-Synuclein (Tyr136) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1635 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 15.63-1000 pg/ml

Rat SNCA / Alpha-Synuclein ELISA Kit (Sandwich ELISA) - LS-F9636 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 5.9 pg/ml Range 15.63-1000 pg/ml

Human SNCA / Alpha-Synuclein ELISA Kit (Sandwich ELISA) - LS-F12684 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 15.6 Range 15.63-1000 pg/ml

Alpha-synuclein, SNCA, Human, ELISA Kit - E1222h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 15.6-1000 pg/mL

Synuclein Alpha, SNCa, Human, ELISA Kit - E-EL-H0983 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Synuclein, alpha (non A4 component of amyloid precursor) oligomer (SNCA oligomer), Human, ELISA Kit - CSB-E18033h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Synuclein, Alpha, SNCa, Mouse, ELISA Kit - E-EL-M1109 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Synuclein Alpha, SNCa, Rat, ELISA Kit - E-EL-R1217 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Synuclein Alpha, SNCa, Rabbit, ELISA Kit - E-EL-RB0882 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Synuclein Alpha, SNCa, Chicken, ELISA Kit - E-EL-Ch0667 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Synuclein Alpha, SNCa, Porcine, ELISA Kit - E-EL-P2188 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Synuclein Alpha, SNCa, Sheep, ELISA Kit - E-EL-S0653 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Synuclein Alpha, SNCa, Monkey, ELISA Kit - E-EL-MK2100 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

SNCA (Human) IP-WB Antibody Pair - H00006622-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

SNCA (Human) Matched Antibody Pair - H00006622-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human SNCa ELISA Kit - HS0138 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine SNCa ELISA Kit - AS0138 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

SNCa, ELISA Kit - MBS2500656 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Rat SNCalpha is 9.375pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 15.625-1000pg/mL

SNCa, ELISA Kit - MBS2508667 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 9.375pg/mL Range 15.625-1000pg/mL

Synuclein Colorimetric Cell-Based ELISA Kit - CB5672 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

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