SNCA

Gene Symbol	SNCA
Entrez Gene	6622
Alt Symbol	NACP, PARK1, PARK4, PD1
Species	Human
Gene Type	protein-coding
Description	synuclein, alpha (non A4 component of amyloid precursor)
Other Description	alpha-synuclein|non A-beta component of AD amyloid|synuclein alpha-140
Swissprots	P37840 Q6IAU6 Q13701 A8K2A4 Q4JHI3
Accessions	AAC02114 AAG30302 AAG30303 AAS57868 AAS83394 AAY40956 AAY88735 CAS01777 CAS01781 EAX06035 EAX06036 P37840 AI815523 AK290169 BAF82858 AY049786 AAL15443 BC013293 AAH13293 BC108275 AAI08276 CR457058 CAG33339 CR541653 CAG46454 CR736451 D31839 BAA06625 DA391115 DQ892564 ABM83490 EU176705 ABW03506 HQ830267 AEG20815 HQ830268 AEG20816 HQ830269 AEG20817 JN709859 AFA25669 JN709860 AFA25670 JN709861 AFA25671 JN709862 AFA25672 JN709863 AFA25673 JN709864 AFA25674 JN709865 AFA25675 JN709866 AFA25676 JN709867 AFA25677 JN709868 AFA25678 JN709869 AFA25679 L08850 AAA16117 L36674 AAA98493 L36675 AAA98487 XM_011532203 XP_011530505 XM_011532204 XP_011530506 XM_011532205 XP_011530507 XM_011532206 XP_011530508 XM_011532207 XP_011530509 XM_011532208 XP_011530510 NM_000345 NP_000336 NM_001146054 NP_001139526 NM_001146055 NP_001139527 NM_007308 NP_009292
Function	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular Location	Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Top Pathways	Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human alpha Synuclein full length protein - ab189694 from Abcam Category Protein Prices $682.00 Sizes 500 µg Source E. coli Species Human

alpha Synuclein (phospho S129) peptide - ab188826 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

alpha Synuclein peptide - ab105629 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human alpha Synuclein (phospho Y125) peptide - ab17030 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human alpha Synuclein full length protein - ab51189 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Human alpha Synuclein full length protein - ab51188 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab123758 from Abcam Category Protein Prices $188.00 Sizes 20 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab172842 from Abcam Category Protein Prices $42.00 Sizes 10 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab51181 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab51183 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab51184 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein full length protein - ab125808 from Abcam Category Protein Prices $188.00 Sizes 100 µg Source E. coli Species Human

Human alpha Synuclein peptide - ab17041 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human alpha Synuclein peptide - ab49441 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human alpha Synuclein protein fragment - ab48842 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab124311 from Abcam Category Protein Prices $235.00 Sizes 200 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab51173 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab51176 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab51178 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab51180 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab51186 from Abcam Category Protein Prices $188.00, $577.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab125482 from Abcam Category Protein Prices $188.00 Sizes 100 µg Source E. coli Species Human

Human alpha Synuclein protein fragment - ab125833 from Abcam Category Protein Prices $188.00 Sizes 100 µg Source E. coli Species Human

SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E8221 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNCA / Alpha-Synuclein Antibody Blocking Peptide - LS-E8224 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

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