SNCA

Gene Symbol SNCA
Entrez Gene 6622
Alt Symbol NACP, PARK1, PARK4, PD1
Species Human
Gene Type protein-coding
Description synuclein, alpha (non A4 component of amyloid precursor)
Other Description alpha-synuclein|non A-beta component of AD amyloid|synuclein alpha-140
Swissprots P37840 Q6IAU6 Q13701 A8K2A4 Q4JHI3
Accessions AAC02114 AAG30302 AAG30303 AAS57868 AAS83394 AAY40956 AAY88735 CAS01777 CAS01781 EAX06035 EAX06036 P37840 AI815523 AK290169 BAF82858 AY049786 AAL15443 BC013293 AAH13293 BC108275 AAI08276 CR457058 CAG33339 CR541653 CAG46454 CR736451 D31839 BAA06625 DA391115 DQ892564 ABM83490 EU176705 ABW03506 HQ830267 AEG20815 HQ830268 AEG20816 HQ830269 AEG20817 JN709859 AFA25669 JN709860 AFA25670 JN709861 AFA25671 JN709862 AFA25672 JN709863 AFA25673 JN709864 AFA25674 JN709865 AFA25675 JN709866 AFA25676 JN709867 AFA25677 JN709868 AFA25678 JN709869 AFA25679 L08850 AAA16117 L36674 AAA98493 L36675 AAA98487 XM_011532203 XP_011530505 XM_011532204 XP_011530506 XM_011532205 XP_011530507 XM_011532206 XP_011530508 XM_011532207 XP_011530509 XM_011532208 XP_011530510 NM_000345 NP_000336 NM_001146054 NP_001139526 NM_001146055 NP_001139527 NM_007308 NP_009292
Function May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular Location Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Note=Membrane-bound in dopaminergic neurons.
Tissue Specificity Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Top Pathways Alzheimer's disease

α-synuclein siRNA (h) - sc-29619 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-synuclein shRNA Plasmid (h) - sc-29619-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-synuclein shRNA (h) Lentiviral Particles - sc-29619-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-synuclein CRISPR/Cas9 KO Plasmid (h) - sc-417273 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein HDR Plasmid (h) - sc-417273-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein Double Nickase Plasmid (h) - sc-417273-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein Double Nickase Plasmid (h2) - sc-417273-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein CRISPR Activation Plasmid (h) - sc-417273-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein CRISPR Activation Plasmid (h2) - sc-417273-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein Lentiviral Activation Particles (h) - sc-417273-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-synuclein Lentiviral Activation Particles (h2) - sc-417273-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Synuclein-alpha RNAi - H00006622-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU095611 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU140811 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19860 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19860 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08044 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08044

SNCA siRNA (Human) - CRH4505 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

alpha-Synuclein RNAi - H00006622-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SNCA - MBS8200274 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SNCA shRNA Plasmid (Human) - CHH4505 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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