PPARA

Gene Symbol PPARA
Entrez Gene 5465
Alt Symbol NR1C1, PPAR, PPARalpha, hPPAR
Species Human
Gene Type protein-coding
Description peroxisome proliferator-activated receptor alpha
Other Description PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3
Swissprots Q9Y3N1 Q07869 Q6I9S0 Q92486 B0G0X3 Q16241 Q92689
Accessions AAO13489 ABI52417 CAD55571 CAI22450 CAQ09265 CAQ09266 CAQ09267 CBX54356 EAW73402 EAW73403 EAW73404 Q07869 AB073605 AB307690 BAH02281 AF018254 AF086231 AF270490 AK024738 AK027101 AK091885 AK289821 BAF82510 AK311946 BAG34887 AU099251 AU104848 AY258326 AAO89521 AY258327 AAO89522 AY258328 AAO89523 AY258329 AAO89524 AY258330 AAO89525 AY258331 AAO89526 BC000052 BC004162 BC009069 BC071932 BQ024839 CR456547 CAG30433 CR457435 CAG33716 CU013147 CAK54578 CU013435 CAK54877 EU395809 ABY73535 EU650667 ACD12656 HQ692862 ADZ17373 L02932 AAA36468 S74349 AAB32649 Y07619 CAA68898 Y16186 CAA76112 XM_005261655 XP_005261712 XM_005261656 XP_005261713 XM_006724269 XP_006724332 XM_006724270 XP_006724333 XM_011530239 XP_011528541 XM_011530240 XP_011528542 XM_011530241 XP_011528543 XM_011530242 XP_011528544 XM_011530243 XP_011528545 XM_011530244 XP_011528546 XM_011530245 XP_011528547 XR_937869 XR_937870 NM_001001928 NP_001001928 NM_005036 NP_005027 NM_001001929 NM_001001930 NM_032644
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
Subcellular Location Nucleus.
Tissue Specificity Skeletal muscle, liver, heart and kidney. {ECO:0000269|PubMed:7981125, ECO:0000269|PubMed:8993548}.
Top Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), cAMP signaling pathway

PPARα (H-98) - sc-9000 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of PPARα expression in Hep G2 whole cell lysate (A) and human recombinant PPARα fusion protein (B). Antibodies tested include PPARα (H-98): sc-9000 (A) and PPARα (N-19): sc-1985 (B).

PPARα (N-19) - sc-1985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PPARα expression in Hep G2 whole cell lysate (A) and human recombinant PPARα fusion protein (B). Antibodies tested include PPARα (H-98): sc-9000 (A) and PPARα (N-19): sc-1985 (B).

PPARα (C-20) - sc-1982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PPARα (H-2) - sc-398394 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PPARα (H-2): sc-398394. Western blot analysis of PPARα expression in non-transfected: sc-117752 (A) and human PPARα transfected: sc-129532 (B) 293T whole cell lysates.

PPARα (467D1a) - sc-130640 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PPARα (467D1a): sc-130640. Western blot analysis of human recombinant PPARα fusion protein.

Anti-PPAR alpha antibody - ab61182 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61182 at 1/100 - 1/500 dilution staining PPAR alpha in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-PPAR alpha antibody - ab45859 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPAR alpha antibody (ab45859) at 1 µg/mlLane 1 : Brain (Mouse) Tissue LysateLane 2 : Testis (Mouse) Tissue Lysate - normal tissueLane 3 : Heart (Mouse) Tissue LysateLane 4 : Skeletal Muscle (Mouse) Tissue Lysate (ab29711)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-PPAR alpha antibody - ab48621 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPAR alpha antibody [1331CT894.186.143] - ab191226 from Abcam

Prices $376.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1331CT894.186.143
All lanes : Anti-PPAR alpha antibody [1331CT894.186.143] (ab191226) at 1/1000 dilutionLane 1 : HeLa cell line lysateLane 2 : Jurkat cell line lysateLane 3 : NIH/3T3 cell line lysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-mouse IgG H&L(HRP) at 1/5000 dilution

Anti-PPAR alpha antibody [1E8] - ab119416 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E8
All lanes : Anti-PPAR alpha antibody [1E8] (ab119416)Lane 1 : HEK293T cells transfected with pCMV6-ENTRY control lysateLane 2 : HEK293T cells transfected with pCMV6-ENTRY PPARA lysateLysates/proteins at 5 µg per lane.

Anti-PPAR alpha antibody (Biotin) - ab48369 from Abcam

Prices $359.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-PPAR alpha antibody [H0723] - ChIP Grade - ab97609 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone H0723

Anti-PPARA / PPAR Alpha Antibody (aa393-412) - LS-C312574 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PPAR Alpha antibody. IHC(P): Human Breast Cancer Tissue.

Anti-PPARA / PPAR Alpha Antibody (clone 3G3) - LS-C173296 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G3
Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.

Anti-PPARA / PPAR Alpha Antibody (clone 2E7) - LS-C173299 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E7
Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.

Anti-PPARA / PPAR Alpha Antibody (clone 467D1a) - LS-C342691 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 467D1a
Western blot analysis of immunized recombinant protein, using anti-PPARA monoclonal antibody.

Anti-PPARA / PPAR Alpha Antibody (N-Terminus) IHC-plus™ - LS-B46 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry using anti-PPAR antibody, showing staining of PPAR alpha in rat brain sections, highlighting cytoplasmic staining in ependymal cells and neurons in frontal cortex. Bottom image shows subventricular zone (svz) of lateral ventrical (exit point of progenitor olfactory neurons); top image shows frontal cortex in the same section. Cytoplasmic staining is also observed in the corpus callosum (bottom image) and in dendritic fields of the cortex. Formalin/PFA-fixed paraffin-embedded sections of rat brain tissue were incubated with the primary antibody at 1:200 for 1 hour. Antigen retrieval was performed by heat induction in citrate buffer pH 6.0.

Anti-PPARA / PPAR Alpha Antibody - LS-C332373 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of 231 cell line, using PPARA antibody.

Anti-PPARA / PPAR Alpha Antibody - LS-C334887 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PPARA antibody.

Anti-PPARA / PPAR Alpha Antibody (aa145-420, clone 2D10) - LS-C340600 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D10
Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.

Anti-PPARA / PPAR Alpha Antibody (aa145-420, clone 2G6) - LS-C337492 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G6
IHC of paraffin-embedded Human prostate tissue using anti-PPARA mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-PPARA / PPAR Alpha Antibody (aa145-420, clone 1E8) - LS-C337491 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E8
Anti-PPARA mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPARA.

Anti-PPARA / PPAR Alpha Antibody (clone 1331CT894.186.143) - LS-C344153 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 1331CT894.186.143
Immunohistochemical of paraffin-embedded H. kidney section using PPARA Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

Anti-PPARA / PPAR Alpha Antibody (aa1-18) - LS-C9672 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPARA / PPAR Alpha Antibody (aa1-18) - LS-C9673 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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