PPARA

Gene Symbol PPARA
Entrez Gene 5465
Alt Symbol NR1C1, PPAR, PPARalpha, hPPAR
Species Human
Gene Type protein-coding
Description peroxisome proliferator-activated receptor alpha
Other Description PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3
Swissprots Q9Y3N1 Q07869 Q6I9S0 Q92486 B0G0X3 Q16241 Q92689
Accessions AAO13489 ABI52417 CAD55571 CAI22450 CAQ09265 CAQ09266 CAQ09267 CBX54356 EAW73402 EAW73403 EAW73404 Q07869 AB073605 AB307690 BAH02281 AF018254 AF086231 AF270490 AK024738 AK027101 AK091885 AK289821 BAF82510 AK311946 BAG34887 AU099251 AU104848 AY258326 AAO89521 AY258327 AAO89522 AY258328 AAO89523 AY258329 AAO89524 AY258330 AAO89525 AY258331 AAO89526 BC000052 BC004162 BC009069 BC071932 BQ024839 CR456547 CAG30433 CR457435 CAG33716 CU013147 CAK54578 CU013435 CAK54877 EU395809 ABY73535 EU650667 ACD12656 HQ692862 ADZ17373 L02932 AAA36468 S74349 AAB32649 Y07619 CAA68898 Y16186 CAA76112 XM_005261655 XP_005261712 XM_005261656 XP_005261713 XM_006724269 XP_006724332 XM_006724270 XP_006724333 XM_011530239 XP_011528541 XM_011530240 XP_011528542 XM_011530241 XP_011528543 XM_011530242 XP_011528544 XM_011530243 XP_011528545 XM_011530244 XP_011528546 XM_011530245 XP_011528547 XR_937869 XR_937870 NM_001001928 NP_001001928 NM_005036 NP_005027 NM_001001929 NM_001001930 NM_032644
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
Subcellular Location Nucleus.
Tissue Specificity Skeletal muscle, liver, heart and kidney. {ECO:0000269|PubMed:7981125, ECO:0000269|PubMed:8993548}.
Top Pathways Adipocytokine signaling pathway, PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), cAMP signaling pathway

PPARα CRISPR/Cas9 KO Plasmid (h) - sc-400238 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα HDR Plasmid (h) - sc-400238-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα Double Nickase Plasmid (h) - sc-400238-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα Double Nickase Plasmid (h2) - sc-400238-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα CRISPR Activation Plasmid (h) - sc-400238-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα CRISPR Activation Plasmid (h2) - sc-400238-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα Lentiviral Activation Particles (h) - sc-400238-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα Lentiviral Activation Particles (h2) - sc-400238-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PPARα siRNA (h) - sc-36307 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPARα shRNA Plasmid (h) - sc-36307-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPARα shRNA (h) Lentiviral Particles - sc-36307-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPARα siRNA (h2) - sc-44323 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPARα shRNA Plasmid (h2) - sc-44323-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPARα shRNA (h2) Lentiviral Particles - sc-44323-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PPAR alpha/NR1C1 RNAi - H00005465-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PPAR alpha/NR1C1 RNAi - H00005465-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PPAR alpha/NR1C1 RNAi - H00005465-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

PPAR alpha/NR1C1 RNAi - H00005465-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151821 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1496 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1494 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1052 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1495 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1494 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1495 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt
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