PPARA

Gene Symbol	PPARA
Entrez Gene	5465
Alt Symbol	NR1C1, PPAR, PPARalpha, hPPAR
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor alpha
Other Description	PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3
Swissprots	Q9Y3N1 Q07869 Q6I9S0 Q92486 B0G0X3 Q16241 Q92689
Accessions	AAO13489 ABI52417 CAD55571 CAI22450 CAQ09265 CAQ09266 CAQ09267 CBX54356 EAW73402 EAW73403 EAW73404 Q07869 AB073605 AB307690 BAH02281 AF018254 AF086231 AF270490 AK024738 AK027101 AK091885 AK289821 BAF82510 AK311946 BAG34887 AU099251 AU104848 AY258326 AAO89521 AY258327 AAO89522 AY258328 AAO89523 AY258329 AAO89524 AY258330 AAO89525 AY258331 AAO89526 BC000052 BC004162 BC009069 BC071932 BQ024839 CR456547 CAG30433 CR457435 CAG33716 CU013147 CAK54578 CU013435 CAK54877 EU395809 ABY73535 EU650667 ACD12656 HQ692862 ADZ17373 L02932 AAA36468 S74349 AAB32649 Y07619 CAA68898 Y16186 CAA76112 XM_005261655 XP_005261712 XM_005261656 XP_005261713 XM_006724269 XP_006724332 XM_006724270 XP_006724333 XM_011530239 XP_011528541 XM_011530240 XP_011528542 XM_011530241 XP_011528543 XM_011530242 XP_011528544 XM_011530243 XP_011528545 XM_011530244 XP_011528546 XM_011530245 XP_011528547 XR_937869 XR_937870 NM_001001928 NP_001001928 NM_005036 NP_005027 NM_001001929 NM_001001930 NM_032644
Function	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
Subcellular Location	Nucleus.
Tissue Specificity	Skeletal muscle, liver, heart and kidney. {ECO:0000269|PubMed:7981125, ECO:0000269|PubMed:8993548}.
Top Pathways	Adipocytokine signaling pathway, PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPAR alpha full length protein - ab81927 from Abcam Category Protein Source E. coli Species Human

Human PPAR alpha full length protein - ab81925 from Abcam Category Protein Source E. coli Species Human

Human PPAR alpha protein fragment - ab81926 from Abcam Category Protein Source E. coli Species Human

Human PPAR alpha protein fragment - ab82045 from Abcam Category Protein Source E. coli Species Human

Mouse PPAR alpha peptide - ab46188 from Abcam Category Peptide

PPAR alpha peptide - ab4998 from Abcam Category Peptide

PPAR alpha peptide - ab4999 from Abcam Category Peptide

PPARA / PPAR Alpha Antibody Blocking Peptide - LS-E2038 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARA / PPAR Alpha Antibody Blocking Peptide - LS-E12044 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARA / PPAR Alpha Antibody Blocking Peptide - LS-E12060 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARA / PPAR Alpha Antibody Blocking Peptide - LS-E12059 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARA / PPAR Alpha Antibody Blocking Peptide - LS-E11648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PPAR alpha/NR1C1 Protein - H00005465-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PPARA-Antibody-Center-Blocking-peptide - BP12910c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PPARa Protein - abx068494 from Abbexa Category Protein Source E.coli Species Human

PPAR-alpha - H00005465-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPAR-alpha - H00005465-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPAR-alpha control peptide - SP5297CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Peroxisome Proliferator Activated Receptor Alpha - 20-7324 from ARP American Research Products Category Protein Prices $539.00 Sizes 50 µg Source E.coli Species Human

PPARA fusion protein - ag17600 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PPARA fusion protein - Ag7896 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PPARA fusion protein - ag17192 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PPARA fusion protein - ag7932 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant PPARα-LBD protein - 31141 from ActiveMotif Category Protein Prices $425.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human PPARA, His-tagged - PPARA-2740H from Creative Biomart Category Protein Source E. coli .

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