PPARA

Gene Symbol	PPARA
Entrez Gene	5465
Alt Symbol	NR1C1, PPAR, PPARalpha, hPPAR
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor alpha
Other Description	PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3
Swissprots	Q9Y3N1 Q07869 Q6I9S0 Q92486 B0G0X3 Q16241 Q92689
Accessions	AAO13489 ABI52417 CAD55571 CAI22450 CAQ09265 CAQ09266 CAQ09267 CBX54356 EAW73402 EAW73403 EAW73404 Q07869 AB073605 AB307690 BAH02281 AF018254 AF086231 AF270490 AK024738 AK027101 AK091885 AK289821 BAF82510 AK311946 BAG34887 AU099251 AU104848 AY258326 AAO89521 AY258327 AAO89522 AY258328 AAO89523 AY258329 AAO89524 AY258330 AAO89525 AY258331 AAO89526 BC000052 BC004162 BC009069 BC071932 BQ024839 CR456547 CAG30433 CR457435 CAG33716 CU013147 CAK54578 CU013435 CAK54877 EU395809 ABY73535 EU650667 ACD12656 HQ692862 ADZ17373 L02932 AAA36468 S74349 AAB32649 Y07619 CAA68898 Y16186 CAA76112 XM_005261655 XP_005261712 XM_005261656 XP_005261713 XM_006724269 XP_006724332 XM_006724270 XP_006724333 XM_011530239 XP_011528541 XM_011530240 XP_011528542 XM_011530241 XP_011528543 XM_011530242 XP_011528544 XM_011530243 XP_011528545 XM_011530244 XP_011528546 XM_011530245 XP_011528547 XR_937869 XR_937870 NM_001001928 NP_001001928 NM_005036 NP_005027 NM_001001929 NM_001001930 NM_032644
Function	Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
Subcellular Location	Nucleus.
Tissue Specificity	Skeletal muscle, liver, heart and kidney. {ECO:0000269|PubMed:7981125, ECO:0000269|PubMed:8993548}.
Top Pathways	Adipocytokine signaling pathway, PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD), cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PPAR (alpha, delta, gamma) Transcription Factor Assay Kit - ab133113 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

PPAR alpha Transcription Factor Assay Kit - ab133107 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

Human PPARA / PPAR Alpha ELISA Kit (Sandwich ELISA) - LS-F4715 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Mouse PPARA / PPAR Alpha ELISA Kit (Sandwich ELISA) - LS-F4716 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.313-20 ng/ml

Mouse/Human/Rat PPARA / PPAR Alpha ELISA Kit (DNA-Binding ELISA) - LS-F791 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.313-20 ng/ml

Rat PPARA / PPAR Alpha ELISA Kit (Sandwich ELISA) - LS-F9236 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Mouse PPARA / PPAR Alpha ELISA Kit (Sandwich ELISA) - LS-F12375 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

PPARA/PPARD/PPARG Complete Transcription Factor Colorimetric Assay Kit - KA1357 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

PPAR alpha/NR1C1 Colorimetric Assay Kit - KA1356 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Human PPARa ELISA kit - 55R-2131 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Mouse PPARa ELISA kit - 55R-2148 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Rat PPARa ELISA kit - 55R-2115 from Fitzgerald Category ELISA Kit Prices $545.00 Sizes 96 tests

Human PPARa ELISA Kit - abx152805 from Abbexa Category ELISA Kit Sensitivity 0.052 ng/ml Range 0.156 ng/ml - 10 ng/ml

Peroxisome Proliferator Activated Receptor Alpha (PPARa), Human, ELISA Kit - SEA934Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.052ng/mL Range 0.156-10ng/mL

Peroxisome proliferator-activated receptor alpha, PPARA, Human, ELISA Kit - E0934h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Peroxisome proliferators activator receptors alpha, PPAR-_, Human, ELISA Kit - CSB-E09754h from ARP American Research Products Category ELISA Kit Prices $365.00, $495.00, $496.00, $498.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Peroxisome Proliferator Activated Receptor Alpha, PPAR-a, Human, ELISA Kit - E-EL-H1360 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

PPARA/PPARD/PPARG Complete Transcription Factor Assay Kit - KA1357 from Acris Antibodies Category ELISA Kit Prices $560.00 Sizes 1 kit

PPARA Transcription Factor Assay Kit - KA1356 from Acris Antibodies Category ELISA Kit Prices $560.00 Sizes 1 kit

Peroxisome proliferators activator alpha, ELISA Kit - MBS734246 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Peroxisome proliferators activator alpha, ELISA Kit - MBS743470 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Peroxisome proliferators activator alpha, ELISA Kit - MBS737076 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Peroxisome proliferators activator Alpha, ELISA Kit - MBS721466 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

Peroxisome proliferators activator alpha, ELISA Kit - MBS724540 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Peroxisome Proliferators activator alpha, ELISA Kit - MBS729154 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

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