SPAST

Gene Symbol	SPAST
Entrez Gene	6683
Alt Symbol	ADPSP, FSP2, SPG4
Species	Human
Gene Type	protein-coding
Description	spastin
Other Description	spastic paraplegia 4 (autosomal dominant; spastin)|spastic paraplegia 4 protein
Swissprots	A7E2A7 Q9UPR9 Q9UBP0
Accessions	ADP91574 ADP91575 ADP91576 ADP91577 ADP91578 ADP91579 ADP91580 ADP91581 ADP91582 ADP91583 ADP91584 ADP91585 ADP91586 ADP91587 ADP91588 ADP91589 ADP91590 ADP91591 ADP91592 ADP91593 ADP91594 ADP91595 ADP91596 ADP91597 ADP91598 ADP91599 ADP91600 ADP91601 ADP91602 ADP91603 ADP91604 ADP91605 ADP91606 ADP91607 ADP91608 ADP91609 ADP91610 ADP91611 ADP91612 ADP91613 ADP91614 ADP91615 ADP91616 ADP91617 ADP91618 ADP91619 ADP91620 ADP91621 ADP91622 ADP91623 ADP91624 ADP91625 ADP91626 ADP91627 ADP91628 ADP91629 ADP91630 ADP91631 ADP91632 ADP91633 ADP91634 ADP91635 ADP91636 ADP91637 ADP91638 ADP91639 ADP91640 ADP91641 ADP91642 ADP91643 ADP91644 ADP91645 ADP91646 ADP91647 ADP91648 ADP91649 ADP91650 ADP91651 ADP91652 ADP91653 CAB60208 EAX00461 EAX00462 Q9UBP0 AA830062 AB029006 BAA83035 AJ246001 CAB60141 AK304135 BAG65029 BC150260 AAI50261 BG532310 XM_005264516 XP_005264573 XM_011533067 XP_011531369 NM_014946 NP_055761 NM_199436 NP_955468
Function	ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. {ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:22637577}.
Subcellular Location	Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Isoform 3 is the main endosomal form.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord. {ECO:0000269|PubMed:10610178}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Spastin (SPAST), Human, ELISA Kit - E01S0395 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Spastin (SPAST), ELISA Kit - MBS7230989 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7237906 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7201300 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7233593 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7230268 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9313352 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.625 ng/ml - 20 ng/ml.

Spastin (SPAST), ELISA Kit - MBS7224152 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7238488 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7226978 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Spastin (SPAST), ELISA Kit - MBS7223403 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7219105 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS7252718 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SPAST ELISA Kit - E036304 from Biobool Category ELISA Kit

Human Spastin ELISA Kit - E098521 from Biobool Category ELISA Kit

Spastin (SPAST), ELISA Kit - MBS9395800 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395808 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395793 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395796 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395794 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395795 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395799 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395804 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395797 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spastin (SPAST), ELISA Kit - MBS9395801 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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