SPAST

Gene Symbol SPAST
Entrez Gene 6683
Alt Symbol ADPSP, FSP2, SPG4
Species Human
Gene Type protein-coding
Description spastin
Other Description spastic paraplegia 4 (autosomal dominant; spastin)|spastic paraplegia 4 protein
Swissprots A7E2A7 Q9UPR9 Q9UBP0
Accessions ADP91574 ADP91575 ADP91576 ADP91577 ADP91578 ADP91579 ADP91580 ADP91581 ADP91582 ADP91583 ADP91584 ADP91585 ADP91586 ADP91587 ADP91588 ADP91589 ADP91590 ADP91591 ADP91592 ADP91593 ADP91594 ADP91595 ADP91596 ADP91597 ADP91598 ADP91599 ADP91600 ADP91601 ADP91602 ADP91603 ADP91604 ADP91605 ADP91606 ADP91607 ADP91608 ADP91609 ADP91610 ADP91611 ADP91612 ADP91613 ADP91614 ADP91615 ADP91616 ADP91617 ADP91618 ADP91619 ADP91620 ADP91621 ADP91622 ADP91623 ADP91624 ADP91625 ADP91626 ADP91627 ADP91628 ADP91629 ADP91630 ADP91631 ADP91632 ADP91633 ADP91634 ADP91635 ADP91636 ADP91637 ADP91638 ADP91639 ADP91640 ADP91641 ADP91642 ADP91643 ADP91644 ADP91645 ADP91646 ADP91647 ADP91648 ADP91649 ADP91650 ADP91651 ADP91652 ADP91653 CAB60208 EAX00461 EAX00462 Q9UBP0 AA830062 AB029006 BAA83035 AJ246001 CAB60141 AK304135 BAG65029 BC150260 AAI50261 BG532310 XM_005264516 XP_005264573 XM_011533067 XP_011531369 NM_014946 NP_055761 NM_199436 NP_955468
Function ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. {ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:22637577}.
Subcellular Location Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Isoform 3 is the main endosomal form.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord. {ECO:0000269|PubMed:10610178}.

Spastin CRISPR/Cas9 KO Plasmid (h) - sc-402225 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin HDR Plasmid (h) - sc-402225-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin Double Nickase Plasmid (h) - sc-402225-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin Double Nickase Plasmid (h2) - sc-402225-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin CRISPR Activation Plasmid (h) - sc-402225-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin CRISPR Activation Plasmid (h2) - sc-402225-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin Lentiviral Activation Particles (h) - sc-402225-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin Lentiviral Activation Particles (h2) - sc-402225-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Spastin siRNA (h) - sc-61603 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spastin shRNA Plasmid (h) - sc-61603-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spastin shRNA (h) Lentiviral Particles - sc-61603-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Spastin RNAi - H00006683-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Spastin RNAi - H00006683-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU073281 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20409 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20409 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPAST siRNA (Human) - CRH4556 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPAST - MBS8216319 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Spast (NM_199436.1) - SHH415996 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPAST(NM_014946.3) - SHL026378 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPAST(NM_199436.1) - SHL026414 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPAST siRNA - orb265058 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPAST shRNA Plasmid (Human) - CHH4556 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPAST miRNA 3'UTR clone - MiUTR1H-09812 from Creative biogene

Species Reactivities Human

SPAST miRNA 3'UTR clone - MiUTR1H-09813 from Creative biogene

Species Reactivities Human
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