SPAST

Gene Symbol	SPAST
Entrez Gene	6683
Alt Symbol	ADPSP, FSP2, SPG4
Species	Human
Gene Type	protein-coding
Description	spastin
Other Description	spastic paraplegia 4 (autosomal dominant; spastin)|spastic paraplegia 4 protein
Swissprots	A7E2A7 Q9UPR9 Q9UBP0
Accessions	ADP91574 ADP91575 ADP91576 ADP91577 ADP91578 ADP91579 ADP91580 ADP91581 ADP91582 ADP91583 ADP91584 ADP91585 ADP91586 ADP91587 ADP91588 ADP91589 ADP91590 ADP91591 ADP91592 ADP91593 ADP91594 ADP91595 ADP91596 ADP91597 ADP91598 ADP91599 ADP91600 ADP91601 ADP91602 ADP91603 ADP91604 ADP91605 ADP91606 ADP91607 ADP91608 ADP91609 ADP91610 ADP91611 ADP91612 ADP91613 ADP91614 ADP91615 ADP91616 ADP91617 ADP91618 ADP91619 ADP91620 ADP91621 ADP91622 ADP91623 ADP91624 ADP91625 ADP91626 ADP91627 ADP91628 ADP91629 ADP91630 ADP91631 ADP91632 ADP91633 ADP91634 ADP91635 ADP91636 ADP91637 ADP91638 ADP91639 ADP91640 ADP91641 ADP91642 ADP91643 ADP91644 ADP91645 ADP91646 ADP91647 ADP91648 ADP91649 ADP91650 ADP91651 ADP91652 ADP91653 CAB60208 EAX00461 EAX00462 Q9UBP0 AA830062 AB029006 BAA83035 AJ246001 CAB60141 AK304135 BAG65029 BC150260 AAI50261 BG532310 XM_005264516 XP_005264573 XM_011533067 XP_011531369 NM_014946 NP_055761 NM_199436 NP_955468
Function	ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. {ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:16219033, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:22637577}.
Subcellular Location	Membrane {ECO:0000255|HAMAP-Rule:MF_03021}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03021}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Endoplasmic reticulum. Endosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Isoform 3 is the main endosomal form.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. The short isoforms may predominate in brain and spinal cord. {ECO:0000269|PubMed:10610178}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Spastin protein fragment - ab152700 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Spastin Protein - H00006683-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Spastin / SPAST - H00006683-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Spastin / SPAST - H00006683-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Spastin / SPAST control peptide - BP964CP1 from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SPAST fusion protein - Ag18797 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SPAST fusion protein - Ag18866 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SPAST, GST-tagged - SPAST-2901H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Spastin(SPAST) - CSB-YP022488HU CSB-EP022488HU CSB-BP022488HU CSB-MP022488HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Spastin / SPAST (transcript variant 2) - TP314100 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Spastin / SPAST (transcript variant 1) - TP320458 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Spastin Recombinant Protein Antigen - NBP1-90230PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SYNTHETIC Human SPASTIN Protein (OPSA10603) - OPSA10603 from Aviva Systems Biology Category Protein Prices $160.00 Sizes 50 µg Species Human

SPAST Peptide, Human - M34GP14973H from Creative Peptides Category Peptide Source Synthetic. Species Human

Spastin, Recombinant Protein - MBS7038910 from MyBioSource Category Protein Prices $1,390.00, $2,375.00, $3,585.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli

Spastin (spas), Recombinant Protein - MBS7057110 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

Spastin (spas), Recombinant Protein - MBS1212896 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

Spastin (spas), Recombinant Protein - MBS7030243 from MyBioSource Category Protein Prices $1,440.00, $2,425.00, $3,630.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli

Spastin (spas), Recombinant Protein - MBS7057127 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

Spastin (SPAST), Recombinant Protein - MBS7057126 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Spastin (v1g144095), Recombinant Protein - MBS1048428 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

Spastin (v1g144095), Recombinant Protein - MBS7057129 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell

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