| Gene Symbol | KAT5 |
|---|---|
| Entrez Gene | 10524 |
| Alt Symbol | ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | K(lysine) acetyltransferase 5 |
| Other Description | 60 kDa Tat-interactive protein|HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA(2)-interacting protein|cPLA2 interacting protein|histone acetyltransferase HTATIP|histone acetyltransferase KAT5 |
| Swissprots | Q92993 Q9BWK7 C9JL99 O95624 Q13430 Q6GSE8 Q561W3 B4E3C7 Q17RW5 |
| Accessions | AAO21130 EAW74427 EAW74428 EAW74429 EAW74430 EAW74431 EAW74432 Q92993 AB209813 BAD93050 AK130717 AK225100 AK226002 AK304664 BAG65439 AK313297 BAG36104 BC000166 AAH00166 BC013211 BC064912 AAH64912 BC093032 AAH93032 BC117167 AAI17168 BC143290 BC143296 AAI43297 BG720537 BI463394 BU737532 DA043042 DB003934 DB103287 HQ258620 ADR83372 U40989 AAB02683 U67734 AAD00163 U74667 AAB18236 XM_006718421 XP_006718484 XM_011544733 XP_011543035 NM_001206833 NP_001193762 NM_006388 NP_006379 NM_182709 NP_874368 NM_182710 NP_874369 |
| Function | Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:17360565}. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies. |
| Top Pathways | HTLV-I infection |