KAT5

Gene Symbol KAT5
Entrez Gene 10524
Alt Symbol ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2
Species Human
Gene Type protein-coding
Description K(lysine) acetyltransferase 5
Other Description 60 kDa Tat-interactive protein|HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA(2)-interacting protein|cPLA2 interacting protein|histone acetyltransferase HTATIP|histone acetyltransferase KAT5
Swissprots Q92993 Q9BWK7 C9JL99 O95624 Q13430 Q6GSE8 Q561W3 B4E3C7 Q17RW5
Accessions AAO21130 EAW74427 EAW74428 EAW74429 EAW74430 EAW74431 EAW74432 Q92993 AB209813 BAD93050 AK130717 AK225100 AK226002 AK304664 BAG65439 AK313297 BAG36104 BC000166 AAH00166 BC013211 BC064912 AAH64912 BC093032 AAH93032 BC117167 AAI17168 BC143290 BC143296 AAI43297 BG720537 BI463394 BU737532 DA043042 DB003934 DB103287 HQ258620 ADR83372 U40989 AAB02683 U67734 AAD00163 U74667 AAB18236 XM_006718421 XP_006718484 XM_011544733 XP_011543035 NM_001206833 NP_001193762 NM_006388 NP_006379 NM_182709 NP_874368 NM_182710 NP_874369
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated
Subcellular Location Nucleus {ECO:0000269|PubMed:17360565}. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
Top Pathways HTLV-I infection

Tip60 Antibody - 12058 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected (-) or transfected with a construct expressing full-length human Tip60 (hTip60; +), using Tip60 Antibody.

TIP60 (K-17) - sc-5727 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIP60 (K-17): sc-5727. Western blot analysis of TIP60 expression in Jurkat (A), CCRF-CEM (B) and IMR-32 (C) nuclear extracts.

TIP60 (H-93) - sc-25378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIP60 (H-93): sc-25378. Western blot analysis of TIP60 expression in Jurkat (A), CCRF-CEM (B) and IMR-32 (C) nuclear extracts.

TIP60 (3F9G7) - sc-81164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TIP60 (N-17) - sc-5725 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIP60 (N-17): sc-5725. Western blot analysis of TIP60 expression in SK-BR-3 (A), KNRK (B) and IMR-32 (C) nuclear extracts.

TIP60 (T4D2) - sc-81757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TIP60 (C-7) - sc-166323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIP60 (C-7): sc-166323. Western blot analysis of TIP60 expression in non-transfected: sc-117752 (A) and human TIP60 transfected: sc-117021 (B) 293T whole cell lysates.

Anti-KAT5 / Tip60 (phospho S86) antibody - ab73207 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT5 / Tip60 (phospho S86) antibody (ab73207) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : Jurkat cell extract with immunising phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-KAT5 / Tip60 (phospho S90) antibody - ab111588 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111588, at a 1/50 dilution, staining KAT5 / Tip60 in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

Anti-KAT5 / Tip60 antibody - ab23886 from Abcam

Prices $391.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab23886 staining KAT5 / Tip60 in human primary fibroblasts by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with 0.2% Triton X-100 and blocked with 2% BSA for 1 hour at room temperature. Samples were incubated with primary antibody (1/500 in PBS + 2% BSA) for 2 hours. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG polyclonal (1/500) was used as the secondary antibody.See Abreview

Anti-KAT5 / Tip60 antibody - ab176492 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-KAT5 / Tip60 antibody (ab176492) at 1 µg/mlLane 1 : Human brain lysateLane 2 : Human brain lysate with immunizing peptideLane 3 : Mouse brain lysateLane 4 : Rat brain lysate

Anti-KAT5 / Tip60 antibody - ab14584 from Abcam

Prices $373.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-KAT5 / Tip60 antibody - ab172415 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-KAT5 / Tip60 antibody (ab172415) at 1 µg/mlLane 1 : KAT5 / Tip60 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

Anti-KAT5 / Tip60 antibody - ab75617 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75617, at a 1/10 dilution, staining KAT5 / Tip60 in formalin fixed, paraffin embedded human hepatocarcinoma tissue by Immunohistochemistry. ab75617 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-KAT5 / Tip60 antibody - ab62644 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62644 at a 1/500 dilution. Left image untreated. Right image treated with peptide.

Anti-KAT5 / Tip60 antibody [T4D2] - ab54277 from Abcam

Host Mouse
Clonality Monoclonal
Clone T4D2
Anti-KAT5 / Tip60 antibody [T4D2] (ab54277) at 1/500 dilution + Truncated Tip60 recombinant protein

Anti-KAT5 / Tip60 antibody - Carboxyterminal end - ab59894 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KAT5 / Tip60 antibody - Carboxyterminal end (ab59894) at 1/60 dilution + CEM cell line tissue lysate at 35 µg

Anti-KAT5 / Tip60 antibody - N-terminal - ab135490 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KAT5 / Tip60 antibody - N-terminal (ab135490) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-KAT5 / TIP60 Antibody (aa371-420) - LS-C119194 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using TIP60 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-KAT5 / TIP60 Antibody (aa467-498) - LS-C96631 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-HTATIP antibody in CEM cell line tissue lysate (35 ug/lane). HTATIP(arrow) was detected using the purified antibody.

Anti-KAT5 / cPLA2 / TIP60 Antibody (aa107-156) - LS-C109672 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KAT5 antibody LS-C109672 Western blot of THP-1 cell lysate.

Anti-KAT5 / cPLA2 / TIP60 Antibody (aa395-444) - LS-C109779 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KAT5 antibody LS-C109779 Western blot of COLO205 cell lysate.

Anti-KAT5 / TIP60 Antibody (C-Terminus) - LS-C145801 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KAT5 antibody LS-C145801 Western blot of HT1080 Cell lysate. Antibody concentration 1 ug/ml.

Anti-KAT5 / TIP60 Antibody (N-Terminus) - LS-C145916 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
KAT5 antibody LS-C145916 Western blot of Mouse Thymus lysate. Antibody concentration 1 ug/ml.

Anti-KAT5 / TIP60 Antibody (aa41-71, AP) - LS-C219698 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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