KAT5

Gene Symbol	KAT5
Entrez Gene	10524
Alt Symbol	ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2
Species	Human
Gene Type	protein-coding
Description	K(lysine) acetyltransferase 5
Other Description	60 kDa Tat-interactive protein|HIV-1 Tat interactive protein, 60kDa|K-acetyltransferase 5|Tat interacting protein, 60kDa|cPLA(2)-interacting protein|cPLA2 interacting protein|histone acetyltransferase HTATIP|histone acetyltransferase KAT5
Swissprots	Q92993 Q9BWK7 C9JL99 O95624 Q13430 Q6GSE8 Q561W3 B4E3C7 Q17RW5
Accessions	AAO21130 EAW74427 EAW74428 EAW74429 EAW74430 EAW74431 EAW74432 Q92993 AB209813 BAD93050 AK130717 AK225100 AK226002 AK304664 BAG65439 AK313297 BAG36104 BC000166 AAH00166 BC013211 BC064912 AAH64912 BC093032 AAH93032 BC117167 AAI17168 BC143290 BC143296 AAI43297 BG720537 BI463394 BU737532 DA043042 DB003934 DB103287 HQ258620 ADR83372 U40989 AAB02683 U67734 AAD00163 U74667 AAB18236 XM_006718421 XP_006718484 XM_011544733 XP_011543035 NM_001206833 NP_001193762 NM_006388 NP_006379 NM_182709 NP_874368 NM_182710 NP_874369
Function	Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated
Subcellular Location	Nucleus {ECO:0000269|PubMed:17360565}. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
Top Pathways	HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TIP60 CRISPR/Cas9 KO Plasmid (h) - sc-400810 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 HDR Plasmid (h) - sc-400810-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 Double Nickase Plasmid (h) - sc-400810-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 Double Nickase Plasmid (h2) - sc-400810-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 CRISPR Activation Plasmid (h) - sc-400810-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 CRISPR Activation Plasmid (h2) - sc-400810-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 Lentiviral Activation Particles (h) - sc-400810-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 Lentiviral Activation Particles (h2) - sc-400810-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TIP60 siRNA (h) - sc-37966 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP60 shRNA Plasmid (h) - sc-37966-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP60 shRNA (h) Lentiviral Particles - sc-37966-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TIP60 RNAi - H00010524-R02 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU139921 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10897 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10897 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03793 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03793

KAT5 siRNA (Human) - CRH7151 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TIP60 RNAi - H00010524-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TIP60 RNAi - H00010524-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

KAT5, siRNA - MBS8236054 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Human KAT5 siRNA - orb267653 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KAT5 shRNA Plasmid (Human) - CHH7151 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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