TREM1
| Gene Symbol | TREM1 |
|---|---|
| Entrez Gene | 54210 |
| Alt Symbol | CD354, TREM-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | triggering receptor expressed on myeloid cells 1 |
| Other Description | triggering receptor expressed on monocytes 1|triggering-receptor TREM1 |
| Swissprots | B4DWG2 Q5T2C9 K7EJW1 Q9NP99 Q86YU1 Q53FL8 |
| Accessions | ABB01010 CAJ78384 EAX04043 EAX04044 Q9NP99 AF196329 AAF71694 AF287008 AAF90197 AK130673 AK223264 BAD96984 AK292162 BAF84851 AK301519 BAG63024 AK313104 BAG35927 AY074783 AAL74018 BC017773 AAH17773 DA362458 DA938757 DQ892009 ABM82935 DQ895198 ABM86124 XM_006715117 XP_006715180 XM_011514696 XP_011512998 XM_011514697 XP_011512999 NM_001242589 NP_001229518 NM_001242590 NP_001229519 NM_018643 NP_061113 |
| Function | Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674}. |
| Subcellular Location | Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11922939}. |
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