Gene Symbol | H3F3C |
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Entrez Gene | 440093 |
Alt Symbol | H3.5 |
Species | Human |
Gene Type | protein-coding |
Description | H3 histone, family 3C |
Other Description | histone H3.3C|histone H3.5|histone variant H3.5 |
Swissprots | E9P281 Q6NXT2 |
Accessions | EAW88541 Q6NXT2 AI016942 BC066906 AAH66906 HQ873957 ADW85800 NM_001013699 NP_001013721 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}. |
Subcellular Location | Nucleus. Chromosome. |
Tissue Specificity | Specifically expressed in the seminiferous tubules of testis. {ECO:0000269|PubMed:21274551}. |
Top Pathways | Systemic lupus erythematosus, Alcoholism, Transcriptional misregulation in cancer |
Anti-Histone H3.3C antibody - ab197387 from Abcam
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Anti-Histone H3.3C antibody [EPR10085(B)] - ab150417 from Abcam
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Anti-H3F3C antibody produced in rabbit - SAB4301146 from Sigma-Aldrich
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H3F3C Antibody (OALA06947) - OALA06947 from Aviva Systems Biology
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h3f3c antibody - zf124888 from GeneTex
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h3f3c antibody - zf124889 from GeneTex
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HISTONE H3 ACETYLATED, Polyclonal Antibody - MBS223065 from MyBioSource
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H3F3C Antibody - 35766 from Signalway Antibody
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H3F3C Polyclonal Antibody - ESAP14389 from Elabscience
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Anti-HISTONE H3 ACETYLATED polyclonal antibody - CPBT-68206RH from Creative Diagnostics
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Anti-H3F3C monoclonal antibody - DCABH-200871 from Creative Diagnostics
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Anti-H3F3C monoclonal antibody, clone FQS21196(C) - DCABH-4085 from Creative Diagnostics
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H3F3C, Polyclonal Antibody - MBS2529948 from MyBioSource
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Anti-Histone H3, clone 1B1-B2 Antibody - MABE923 from EMD Millipore
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Histone H3 Acetylated Antibody - AHP1027 from AbD Serotec
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H3F3C Antibody - CSB-PA179034 from Cusabio
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Histone H3-asymmetric dimethyl arginine 2... - pab0540 from Covalab
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Histone H3 tri methyl K4 antibody (5B7) - mab0074-P from Covalab
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Histone H3 di methyl K9 antibody - pab0189 from Covalab
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Histone H3 citrulline R2 + R8 + R17 antibody - pab0208 from Covalab
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Histone H3 citrulline R2 + R8 + R17 antibody... - mab0072-P from Covalab
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H3F3B antibody (2D7-H1) - mab71594 from Covalab
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Anti-H3F3B Antibody - LS-C358185 from LifeSpan Bioscience
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H3F3C Antibody (OASA07345) - OASA07345 from Aviva Systems Biology
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H3F3C, Polyclonal Antibody - MBS9402362 from MyBioSource
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