| Gene Symbol |
H3F3C
|
| Entrez Gene |
440093
|
| Alt Symbol |
H3.5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
H3 histone, family 3C
|
| Other Description |
histone H3.3C|histone H3.5|histone variant H3.5
|
| Swissprots |
E9P281 Q6NXT2
|
| Accessions |
EAW88541 Q6NXT2 AI016942 BC066906 AAH66906 HQ873957 ADW85800 NM_001013699 NP_001013721
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269|PubMed:21274551}.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Tissue Specificity |
Specifically expressed in the seminiferous tubules of testis. {ECO:0000269|PubMed:21274551}.
|
| Top Pathways |
Systemic lupus erythematosus, Alcoholism, Transcriptional misregulation in cancer
|