MTF2

Gene Symbol	MTF2
Entrez Gene	22823
Alt Symbol	M96, PCL2, TDRD19A, dJ976O13.2
Species	Human
Gene Type	protein-coding
Description	metal response element binding transcription factor 2
Other Description	hPCl2\|metal regulatory transcription factor 2\|metal response element-binding transcription factor 2\|metal-response element DNA-binding protein M96\|metal-response element-binding transcription factor 2\|polycomb-like 2\|polycomb-like protein 2\|putative DNA binding protein\|tudor domain containing 19A
Swissprots	B1AKT6 B1AKT5 A6NGQ9 A8K2Q3 Q9UP40 Q9UES9 Q9Y483
Accessions	EAW73083 EAW73084 EAW73085 Q9Y483 AF072814 AAC27618 AF073293 AAC27080 AF086050 AF086908 AAP97138 AJ010014 CAA08970 AK290318 BAF83007 AK302776 BAG63981 AK302900 BAG64073 BC001897 BC010013 AAH10013 BQ025793 CA417978 DB173315 XM_011541016 XP_011539318 XM_011541017 XP_011539319 XM_011541018 XP_011539320 XM_011541019 XP_011539321 XM_011541020 XP_011539322 NM_001164391 NP_001157863 NM_001164392 NP_001157864 NM_001164393 NP_001157865 NM_007358 NP_031384
Function	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.

MTF-2 (D-16) - sc-165040 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-MTF2 antibody - ab173850 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 antibody (ab173850) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-MTF2 antibody - ab42508 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 antibody (ab42508) at 0.25 µg/ml + HepG2 Cell Lysate

Anti-MTF2 antibody - ab94629 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 antibody (ab94629) at 1 µg/ml (in 5% skim milk / PBS buffer) + THP-1 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MTF2 / PCL2 Antibody (aa289-317) - LS-C158324 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

MTF2 Antibody western blot of A549 cell line lysates (35 ug/lane). The MTF2 antibody detected the MTF2 protein (arrow).

Anti-MTF2 / PCL2 Antibody (aa26-75) - LS-C30059 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa289-317, AP) - LS-C246530 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa289-317, APC) - LS-C246531 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa289-317, Biotin) - LS-C246532 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa359-408) - LS-C109890 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MTF2 antibody LS-C109890 Western blot of THP-1 cell lysate.

Anti-MTF2 / PCL2 Antibody (aa289-317, FITC) - LS-C246533 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa289-317, PE) - LS-C246535 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa289-317, Azide-free, HRP) - LS-C248859 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody (aa288-317) - LS-C329853 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MTF2 / PCL2 Antibody - LS-C346218 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence blot of A549 cell using MTF2 antibody. Blue: DAPI for nuclear staining.

MTF2 Antibody - AF6846 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep
Clonality	Polyclonal

MTF2 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human MTF2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6846) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in hepatocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

MTF2 Antibody - NBP1-80038 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

MTF2 Antibody - NBP1-97438 from Novus Biologicals

Prices	$139.00, $499.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: MTF2 Antibody [NBP1-97438] - Hum. Fetal Heart.

MTF2 Antibody - H00022823-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: MTF2 Antibody [H00022823-B01P] - Analysis of MTF2 expression in transfected 293T cell line by MTF2 polyclonal antibody. Lane 1: MTF2 transfected lysate(58.96 KDa). Lane 2: Non-transfected lysate.

MTF2 Antibody - H00022823-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: MTF2 Antibody [H00022823-D01P] - analysis of MTF2 expression in transfected 293T cell line by MTF2 MaxPab rabbit polyclonal antibody. Lane 1: MTF2 transfected lysate (60.60 KDa). Lane 2: Non-transfected lysate.

Anti-MTF2 antibody produced in rabbit - SAB2104413 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-MTF2, antibody produced in rabbit: <B>Cat. No. SAB2104413</B>: Immunoblotting analysis of MTF2 in THP-1 cell lysate with MTF2 anitbody at 1 μg/mL.

Anti-MTF2 antibody produced in rabbit - SAB1401571 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Polyclonal Anti-MTF2, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401571</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~60.60 kDa using MTF2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-MTF2 antibody produced in mouse - SAB1407145 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-MTF2: <B>Cat. No. SAB1407145</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~59 kDa using MTF2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-M96 antibody produced in rabbit - AV34292 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV34292</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.25 μg/mL in cell type HepG2

MTF2 antibody - middle region (ARP34291_P050) - ARP34291_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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