MTF2

Gene Symbol	MTF2
Entrez Gene	22823
Alt Symbol	M96, PCL2, TDRD19A, dJ976O13.2
Species	Human
Gene Type	protein-coding
Description	metal response element binding transcription factor 2
Other Description	hPCl2|metal regulatory transcription factor 2|metal response element-binding transcription factor 2|metal-response element DNA-binding protein M96|metal-response element-binding transcription factor 2|polycomb-like 2|polycomb-like protein 2|putative DNA binding protein|tudor domain containing 19A
Swissprots	B1AKT6 B1AKT5 A6NGQ9 A8K2Q3 Q9UP40 Q9UES9 Q9Y483
Accessions	EAW73083 EAW73084 EAW73085 Q9Y483 AF072814 AAC27618 AF073293 AAC27080 AF086050 AF086908 AAP97138 AJ010014 CAA08970 AK290318 BAF83007 AK302776 BAG63981 AK302900 BAG64073 BC001897 BC010013 AAH10013 BQ025793 CA417978 DB173315 XM_011541016 XP_011539318 XM_011541017 XP_011539319 XM_011541018 XP_011539320 XM_011541019 XP_011539321 XM_011541020 XP_011539322 NM_001164391 NP_001157863 NM_001164392 NP_001157864 NM_001164393 NP_001157865 NM_007358 NP_031384
Function	Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTF2 full length protein - ab161435 from Abcam Category Protein Source Wheat germ Species Human

MTF2 / PCL2 Antibody Blocking Peptide - LS-E5744 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MTF2 / PCL2 Antibody Blocking Peptide - LS-E12137 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MTF2 / PCL2 Antibody Blocking Peptide - LS-E12138 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MTF2 Protein - H00022823-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MTF2-Antibody-Center-Blocking-Peptide - BP18277c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

M96 Blocking Peptide - 33R-9414 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MTF2 - H00022823-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MTF2 fusion protein - Ag9182 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MTF2 fusion protein - ag9384 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human MTF2, GST-tagged - MTF2-1079H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Metal-response element-binding transcription factor 2(MTF2) - CSB-YP896720HU CSB-EP896720HU CSB-BP896720HU CSB-MP896720HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MTF2 Peptide, Human - M34GP09872H from Creative Peptides Category Peptide Source Synthetic. Species Human

MTF2 Recombinant Protein Antigen - NBP2-55885PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Metal-response element-binding transcription factor 2 (MTF2), Recombinant Protein - MBS1347746 from MyBioSource Category Protein Prices $1,395.00, $1,395.00, $1,610.00, $1,610.00, $2,330.00, $2,330.00, $2,770.00, $2,770.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MTF2 Recombinant Protein Antigen - NBP2-56629PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Metal Response Element Binding Transcription Factor 2 (MTF2) - RPU55384 from Biomatik Category Protein Prices $288.00, $358.00, $1,344.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

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