| Gene Symbol |
MTF2
|
| Entrez Gene |
22823
|
| Alt Symbol |
M96, PCL2, TDRD19A, dJ976O13.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
metal response element binding transcription factor 2
|
| Other Description |
hPCl2|metal regulatory transcription factor 2|metal response element-binding transcription factor 2|metal-response element DNA-binding protein M96|metal-response element-binding transcription factor 2|polycomb-like 2|polycomb-like protein 2|putative DNA binding protein|tudor domain containing 19A
|
| Swissprots |
B1AKT6 B1AKT5 A6NGQ9 A8K2Q3 Q9UP40 Q9UES9 Q9Y483
|
| Accessions |
EAW73083 EAW73084 EAW73085 Q9Y483 AF072814 AAC27618 AF073293 AAC27080 AF086050 AF086908 AAP97138 AJ010014 CAA08970 AK290318 BAF83007 AK302776 BAG63981 AK302900 BAG64073 BC001897 BC010013 AAH10013 BQ025793 CA417978 DB173315 XM_011541016 XP_011539318 XM_011541017 XP_011539319 XM_011541018 XP_011539320 XM_011541019 XP_011539321 XM_011541020 XP_011539322 NM_001164391 NP_001157863 NM_001164392 NP_001157864 NM_001164393 NP_001157865 NM_007358 NP_031384
|
| Function |
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
