MTF2

Gene Symbol MTF2
Entrez Gene 22823
Alt Symbol M96, PCL2, TDRD19A, dJ976O13.2
Species Human
Gene Type protein-coding
Description metal response element binding transcription factor 2
Other Description hPCl2|metal regulatory transcription factor 2|metal response element-binding transcription factor 2|metal-response element DNA-binding protein M96|metal-response element-binding transcription factor 2|polycomb-like 2|polycomb-like protein 2|putative DNA binding protein|tudor domain containing 19A
Swissprots B1AKT6 B1AKT5 A6NGQ9 A8K2Q3 Q9UP40 Q9UES9 Q9Y483
Accessions EAW73083 EAW73084 EAW73085 Q9Y483 AF072814 AAC27618 AF073293 AAC27080 AF086050 AF086908 AAP97138 AJ010014 CAA08970 AK290318 BAF83007 AK302776 BAG63981 AK302900 BAG64073 BC001897 BC010013 AAH10013 BQ025793 CA417978 DB173315 XM_011541016 XP_011539318 XM_011541017 XP_011539319 XM_011541018 XP_011539320 XM_011541019 XP_011539321 XM_011541020 XP_011539322 NM_001164391 NP_001157863 NM_001164392 NP_001157864 NM_001164393 NP_001157865 NM_007358 NP_031384
Function Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}.

MTF-2 CRISPR/Cas9 KO Plasmid (h) - sc-411609 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 HDR Plasmid (h) - sc-411609-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 Double Nickase Plasmid (h) - sc-411609-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 Double Nickase Plasmid (h2) - sc-411609-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 CRISPR Activation Plasmid (h) - sc-411609-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 CRISPR Activation Plasmid (h2) - sc-411609-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 Lentiviral Activation Particles (h) - sc-411609-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 Lentiviral Activation Particles (h2) - sc-411609-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTF-2 siRNA (h) - sc-88160 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTF-2 shRNA Plasmid (h) - sc-88160-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTF-2 shRNA (h) Lentiviral Particles - sc-88160-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTF2 RNAi - H00022823-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU042951 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14699 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14699 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05203 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05203

MTF2 siRNA (Human) - CRH7791 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MTF2 (NM_007358.3) - SHH346260 from Creative biogene

Category siRNA
Species Reactivities Human

MTF2 shRNA Plasmid (Human) - CHH7791 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MTF2 miRNA 3'UTR clone - MiUTR1H-06504 from Creative biogene

Species Reactivities Human
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