Gene Symbol | MMP15 |
---|---|
Entrez Gene | 4324 |
Alt Symbol | MT2-MMP, MTMMP2, SMCP-2 |
Species | Human |
Gene Type | protein-coding |
Description | matrix metallopeptidase 15 (membrane-inserted) |
Other Description | MMP-15|MT-MMP 2|MT2MMP|matrix metalloproteinase 15 (membrane-inserted)|matrix metalloproteinase-15|membrane-type matrix metalloproteinase 2|membrane-type-2 matrix metalloproteinase |
Swissprots | P51511 Q14111 A0A2U6 |
Accessions | ABJ53423 EAW82965 EAW82966 P51511 AW161057 BC006412 BC036495 AAH36495 BC055428 AAH55428 BF507560 BT006715 AAP35361 D85510 BAA22225 D86331 BAA13071 Z48482 CAA88373 NM_002428 NP_002419 |
Function | Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. |
Tissue Specificity | Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle. |