Gene Symbol | MMP15 |
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Entrez Gene | 4324 |
Alt Symbol | MT2-MMP, MTMMP2, SMCP-2 |
Species | Human |
Gene Type | protein-coding |
Description | matrix metallopeptidase 15 (membrane-inserted) |
Other Description | MMP-15|MT-MMP 2|MT2MMP|matrix metalloproteinase 15 (membrane-inserted)|matrix metalloproteinase-15|membrane-type matrix metalloproteinase 2|membrane-type-2 matrix metalloproteinase |
Swissprots | P51511 Q14111 A0A2U6 |
Accessions | ABJ53423 EAW82965 EAW82966 P51511 AW161057 BC006412 BC036495 AAH36495 BC055428 AAH55428 BF507560 BT006715 AAP35361 D85510 BAA22225 D86331 BAA13071 Z48482 CAA88373 NM_002428 NP_002419 |
Function | Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. |
Tissue Specificity | Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle. |
MT-MMP-2 CRISPR/Cas9 KO Plasmid (h) - sc-404075 from Santa Cruz Biotechnology
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MT-MMP-2 HDR Plasmid (h) - sc-404075-HDR from Santa Cruz Biotechnology
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MT-MMP-2 Double Nickase Plasmid (h) - sc-404075-NIC from Santa Cruz Biotechnology
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MT-MMP-2 Double Nickase Plasmid (h2) - sc-404075-NIC-2 from Santa Cruz Biotechnology
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MT-MMP-2 CRISPR Activation Plasmid (h) - sc-404075-ACT from Santa Cruz Biotechnology
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MT-MMP-2 CRISPR Activation Plasmid (h2) - sc-404075-ACT-2 from Santa Cruz Biotechnology
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MT-MMP-2 Lentiviral Activation Particles (h) - sc-404075-LAC from Santa Cruz Biotechnology
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MT-MMP-2 Lentiviral Activation Particles (h2) - sc-404075-LAC-2 from Santa Cruz Biotechnology
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MT-MMP-2 siRNA (h) - sc-41567 from Santa Cruz Biotechnology
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MT-MMP-2 shRNA Plasmid (h) - sc-41567-SH from Santa Cruz Biotechnology
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MT-MMP-2 shRNA (h) Lentiviral Particles - sc-41567-V from Santa Cruz Biotechnology
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MMP-15/MT2-MMP RNAi - H00004324-R01 from Novus Biologicals
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MISSION® esiRNA - EHU057241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14426 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14426 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09243 from Sigma-Aldrich
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MMP15 siRNA (Human) - CRH2936 from Cohesion Biosciences
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shRNA set against Human MMP15 (NM_002428.2) - SHH342924 from Creative biogene
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shRNA set against Human MMP15(NM_002428.2) - SHH193439 from Creative biogene
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Human MMP15 siRNA - orb263438 from Biorbyt
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MMP15 shRNA Plasmid (Human) - CHH2936 from Cohesion Biosciences
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MMP15 miRNA 3'UTR clone - MiUTR1H-06348 from Creative biogene
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