| Gene Symbol | SPACA3 |
|---|---|
| Entrez Gene | 124912 |
| Alt Symbol | 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sperm acrosome associated 3 |
| Other Description | cancer/testis antigen 54|lysozyme-like acrosomal sperm-specific secretory protein ALLP-17|lysozyme-like protein 3|lysozyme-like sperm-specific secretory protein ALLP17|sperm acrosome membrane-associated protein 3|sperm lysozyme like protein 1|sperm lysozyme-like protein 1|sperm lyzozyme-like acrosomal protein 1|sperm protein reactive with ASA|sperm protein reactive with antisperm antibodies |
| Swissprots | Q8IXA5 Q7Z4Y5 |
| Accessions | AAP97222 EAW80217 EAW80218 Q8IXA5 AF216311 AAK01478 AY358653 AAQ89016 BC029867 AAH29867 BC100886 AAI00887 BC100887 AAI00888 NM_173847 NP_776246 |
| Function | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269|PubMed:12606493}. |
| Subcellular Location | Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non- capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}. |
| Tissue Specificity | The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}. |