Gene Symbol | SPACA3 |
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Entrez Gene | 124912 |
Alt Symbol | 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1 |
Species | Human |
Gene Type | protein-coding |
Description | sperm acrosome associated 3 |
Other Description | cancer/testis antigen 54|lysozyme-like acrosomal sperm-specific secretory protein ALLP-17|lysozyme-like protein 3|lysozyme-like sperm-specific secretory protein ALLP17|sperm acrosome membrane-associated protein 3|sperm lysozyme like protein 1|sperm lysozyme-like protein 1|sperm lyzozyme-like acrosomal protein 1|sperm protein reactive with ASA|sperm protein reactive with antisperm antibodies |
Swissprots | Q8IXA5 Q7Z4Y5 |
Accessions | AAP97222 EAW80217 EAW80218 Q8IXA5 AF216311 AAK01478 AY358653 AAQ89016 BC029867 AAH29867 BC100886 AAI00887 BC100887 AAI00888 NM_173847 NP_776246 |
Function | Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269|PubMed:12606493}. |
Subcellular Location | Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non- capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}. |
Tissue Specificity | The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}. |
SPACA3 CRISPR/Cas9 KO Plasmid (h) - sc-407167 from Santa Cruz Biotechnology
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SPACA3 HDR Plasmid (h) - sc-407167-HDR from Santa Cruz Biotechnology
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SPACA3 Double Nickase Plasmid (h) - sc-407167-NIC from Santa Cruz Biotechnology
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SPACA3 Double Nickase Plasmid (h2) - sc-407167-NIC-2 from Santa Cruz Biotechnology
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SPACA3 CRISPR Activation Plasmid (h) - sc-407167-ACT from Santa Cruz Biotechnology
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SPACA3 CRISPR Activation Plasmid (h2) - sc-407167-ACT-2 from Santa Cruz Biotechnology
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SPACA3 Lentiviral Activation Particles (h) - sc-407167-LAC from Santa Cruz Biotechnology
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SPACA3 Lentiviral Activation Particles (h2) - sc-407167-LAC-2 from Santa Cruz Biotechnology
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SPACA3 siRNA (h) - sc-93867 from Santa Cruz Biotechnology
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SPACA3 shRNA Plasmid (h) - sc-93867-SH from Santa Cruz Biotechnology
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SPACA3 shRNA (h) Lentiviral Particles - sc-93867-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU007911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20378 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20378 from Sigma-Aldrich
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SPACA3 siRNA (Human) - CRJ4790 from Cohesion Biosciences
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SPACA3 - MBS828964 from MyBioSource
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shRNA set against Human SPACA3 (NM_173847.3) - SHH415720 from Creative biogene
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shRNA set against Human SPACA3(NM_173847.3) - SHL025164 from Creative biogene
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SPACA3 shRNA Plasmid (Human) - CHJ4790 from Cohesion Biosciences
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SPACA3 miRNA 3'UTR clone - MiUTR1H-09784 from Creative biogene
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