TRPC3

Gene Symbol TRPC3
Entrez Gene 7222
Alt Symbol TRP3
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily C, member 3
Other Description hTrp-3|short transient receptor potential channel 3|transient receptor potential cation channel subfamily C member 3 variant c|transient receptor protein 3
Swissprots O00593 E9PCJ9 Q13507 A7VJS1 Q52M35 Q15660 Q5G1L5
Accessions AAY40971 CAJ01297 EAX05243 Q13507 AB255423 BAF76423 AB255424 BAF76424 AY865574 AAW62292 BC093682 AAH93682 BC093684 AAH93684 BC143239 KC207570 AGG20159 X89068 CAA61448 Y13758 CAA74083 XM_011532217 XP_011530519 XM_011532218 XP_011530520 XM_011532219 XP_011530521 NM_001130698 NP_001124170 NM_003305 NP_003296
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. {ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

TRPC3/6/7 (A-15) - sc-15058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPC3/6/7 (A-15): sc-15058. Western blot analysis of TRPC3/6/7 expression in MEG-01 whole cell lysate.

TRPC3/6/7 (H-100) - sc-20111 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPC3/6/7 (H-100): sc-20111. Immunoperoxidase staining of formalin fixed, paraffin-embedded human endometrium tissue showing cytoplasmic staining of cells in endometrial stroma, myometrum and glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

TRPC3/6/7 (N-18) - sc-15056 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPC3/6/7 (N-18): sc-15056. Western blot analysis of human recombinant TRPC3/6/7 fusion protein.

Anti-TRPC3 antibody - ab51560 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody ab51560 at 10 µg/ml.

Anti-TRPC3 antibody - ab104534 from Abcam

Prices $370.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-TRPC3 antibody - ab75171 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPC3 antibody - ab74823 from Abcam

Host Rabbit
Clonality Polyclonal
IHC image of ab74823 staining in rat adult brain formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab74823, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TRPC3 antibody - ab63011 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPC3 antibody - C-terminal - ab188802 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of mouse heart cells, labeling TRPC3 with ab188802 at 20 µg/ml.

Anti-TRPC3 Antibody (C-Terminus) - LS-C132696 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (N-Terminus) - LS-C132697 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, AP) - LS-C218164 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, APC) - LS-C218165 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, Biotin) - LS-C218166 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, FITC) - LS-C218167 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, PE) - LS-C218170 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa765-793, Azide-free, HRP) - LS-C218168 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (aa776-805) - LS-C325983 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPC3 Antibody (N-Terminus) - LS-C112234 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRPC3 antibody LS-C112234 Western blot of HepG2 cell lysate.

Anti-TRPC3 Antibody (aa836-851) - LS-C312898 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TRPC3 antibody. IHC(P): Human Rectal Cancer Tissue.

Anti-TRPC3 Antibody (aa275-325) - LS-C291015 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human TRPC3 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from 293T cells. Antibodies: Affinity purified rabbit anti-TRPC3 antibody used for IP at 6 ug per reaction. TRPC3 was also immunoprecipitated by rabbit anti-TRPC3 antibody BL16089. For blotting immunoprecipitated TRPC3, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-TRPC3 Antibody (aa765-793) - LS-C160228 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of TRPC3 (arrow) using rabbit polyclonal TRPC3 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the TRPC3 gene.

Anti-TRPC3 Antibody (C-Terminus) IHC-plus™ - LS-B187 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPC3 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B187 concentration 5 ug/ml.

Anti-TRPC3 Antibody (N-Terminus) IHC-plus™ - LS-B186 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPC3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B186 concentration 5 ug/ml.

TRPC3 Antibody - NBP1-86266 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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