| Gene Symbol |
TRPC3
|
| Entrez Gene |
7222
|
| Alt Symbol |
TRP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily C, member 3
|
| Other Description |
hTrp-3|short transient receptor potential channel 3|transient receptor potential cation channel subfamily C member 3 variant c|transient receptor protein 3
|
| Swissprots |
O00593 E9PCJ9 Q13507 A7VJS1 Q52M35 Q15660 Q5G1L5
|
| Accessions |
AAY40971 CAJ01297 EAX05243 Q13507 AB255423 BAF76423 AB255424 BAF76424 AY865574 AAW62292 BC093682 AAH93682 BC093684 AAH93684 BC143239 KC207570 AGG20159 X89068 CAA61448 Y13758 CAA74083 XM_011532217 XP_011530519 XM_011532218 XP_011530520 XM_011532219 XP_011530521 NM_001130698 NP_001124170 NM_003305 NP_003296
|
| Function |
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. {ECO:0000269|PubMed:20095964, ECO:0000269|PubMed:8646775, ECO:0000269|PubMed:9417057, ECO:0000269|PubMed:9930701}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
|