Gene Symbol | WWTR1 |
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Entrez Gene | 25937 |
Alt Symbol | TAZ |
Species | Human |
Gene Type | protein-coding |
Description | WW domain containing transcription regulator 1 |
Other Description | WW domain-containing transcription regulator protein 1|transcriptional co-activator with PDZ-binding motif|transcriptional coactivator with PDZ-binding motif |
Swissprots | Q9Y3W6 Q8N3P2 Q9GZV5 D3DNH7 |
Accessions | CAE90288 EAW78868 EAW78869 Q9GZV5 AJ299431 CAC17722 AK022036 BAB13957 AK025216 AK127620 AK130514 AL050107 CAB43275 AL833852 CAD38711 BC014052 AAH14052 DA338432 DA760311 DA854089 DQ893378 ABM84304 DQ896699 ABM87698 XM_011512661 XP_011510963 NM_001168278 NP_001161750 NM_001168280 NP_001161752 NM_015472 NP_056287 |
Function | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15. |
Tissue Specificity | Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}. |
Top Pathways | Hippo signaling pathway |
TAZ (V386) Antibody - 4883 from Cell Signaling Technology
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TAZ Antibody - 2149 from Cell Signaling Technology
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YAP/TAZ (D24E4) Rabbit mAb - 8418 from Cell Signaling Technology
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TAZ (H-70) - sc-48805 from Santa Cruz Biotechnology
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TAZ (G-20) - sc-17131 from Santa Cruz Biotechnology
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TAZ (N-20) - sc-17130 from Santa Cruz Biotechnology
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p-TAZ (Ser 89) - sc-17610 from Santa Cruz Biotechnology
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Anti-TAZ antibody - ab84927 from Abcam
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Anti-TAZ antibody - ab110239 from Abcam
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Anti-TAZ antibody - ab118373 from Abcam
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Anti-TAZ antibody - ab119373 from Abcam
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Anti-TAZ antibody - ab129604 from Abcam
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Anti-TAZ antibody - ab181810 from Abcam
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Anti-TAZ antibody [1B5] - ab119253 from Abcam
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Anti-TAZ antibody - C-terminal - ab202394 from Abcam
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Anti-WWTR1 / TAZ Antibody (aa386-400) - LS-C39554 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody - LS-C90042 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (Biotin) - LS-C141560 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (DY488) - LS-C141562 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (HRP) - LS-C141563 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (DY650) - LS-C141561 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (DY550) - LS-C141564 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (aa369-398, APC) - LS-C242790 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (aa369-398, AP) - LS-C242791 from LifeSpan Bioscience
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Anti-WWTR1 / TAZ Antibody (aa369-398, FITC) - LS-C242792 from LifeSpan Bioscience
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