WWTR1

Gene Symbol WWTR1
Entrez Gene 25937
Alt Symbol TAZ
Species Human
Gene Type protein-coding
Description WW domain containing transcription regulator 1
Other Description WW domain-containing transcription regulator protein 1|transcriptional co-activator with PDZ-binding motif|transcriptional coactivator with PDZ-binding motif
Swissprots Q9Y3W6 Q8N3P2 Q9GZV5 D3DNH7
Accessions CAE90288 EAW78868 EAW78869 Q9GZV5 AJ299431 CAC17722 AK022036 BAB13957 AK025216 AK127620 AK130514 AL050107 CAB43275 AL833852 CAD38711 BC014052 AAH14052 DA338432 DA760311 DA854089 DQ893378 ABM84304 DQ896699 ABM87698 XM_011512661 XP_011510963 NM_001168278 NP_001161750 NM_001168280 NP_001161752 NM_015472 NP_056287
Function Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.
Subcellular Location Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.
Tissue Specificity Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}.
Top Pathways Hippo signaling pathway

TAZ (V386) Antibody - 4883 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using TAZ (V386) Antibody.

TAZ Antibody - 2149 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of A431, HeLa and H1975 cells using TAZ Antibody.

YAP/TAZ (D24E4) Rabbit mAb - 8418 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D24E4
Western blot analysis of extracts from various cell lines using YAP/TAZ (D24E4) Rabbit mAb.

TAZ (H-70) - sc-48805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TAZ (H-70): sc-48805. Immunofluorescence staining of normal mouse liver frozen section showing nuclear staining.

TAZ (G-20) - sc-17131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAZ (G-20): sc-17131. Western blot analysis of TAZ expression in non-transfected 293T: sc-117752 (A) and human TAZ transfected 293T: sc-170455 (B) whole cell lysates.

TAZ (N-20) - sc-17130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TAZ (N-20): sc-17130. Western blot analysis of TAZ expression in non-transfected 293T: sc-117752 (A) and human TAZ transfected 293T: sc-170455 (B) whole cell lysates.

p-TAZ (Ser 89) - sc-17610 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-TAZ (Ser 89)-R: sc-17610-R. Western blot analysis of p-TAZ phosphorylation in NIH/3T3 whole cell lysate.

Anti-TAZ antibody - ab84927 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TAZ antibody - ab110239 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of TAZ staining in Human normal kidney formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab110239, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TAZ antibody - ab118373 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TAZ antibody (ab118373) at 5 µg/ml + Recombinant immunogen at 0.2 µg

Anti-TAZ antibody - ab119373 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TAZ antibody (ab119373) at 1/500 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysate

Anti-TAZ antibody - ab129604 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TAZ antibody (ab129604) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-TAZ antibody - ab181810 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TAZ antibody [1B5] - ab119253 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B5
Immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TAZ, and labelled with ab119253 at 1/100 dilution.

Anti-TAZ antibody - C-terminal - ab202394 from Abcam

Prices $359.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TAZ antibody - C-terminal (ab202394) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Mouse kidney tissue lysateLysates/proteins at 20 µg per lane.SecondaryGoat anti-rabbit IgG H&L(HRP) at 1/10000 dilution

Anti-WWTR1 / TAZ Antibody (aa386-400) - LS-C39554 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody - LS-C90042 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (Biotin) - LS-C141560 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (DY488) - LS-C141562 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (HRP) - LS-C141563 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (DY650) - LS-C141561 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (DY550) - LS-C141564 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (aa369-398, APC) - LS-C242790 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (aa369-398, AP) - LS-C242791 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WWTR1 / TAZ Antibody (aa369-398, FITC) - LS-C242792 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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