WWTR1

Gene Symbol WWTR1
Entrez Gene 25937
Alt Symbol TAZ
Species Human
Gene Type protein-coding
Description WW domain containing transcription regulator 1
Other Description WW domain-containing transcription regulator protein 1|transcriptional co-activator with PDZ-binding motif|transcriptional coactivator with PDZ-binding motif
Swissprots Q9Y3W6 Q8N3P2 Q9GZV5 D3DNH7
Accessions CAE90288 EAW78868 EAW78869 Q9GZV5 AJ299431 CAC17722 AK022036 BAB13957 AK025216 AK127620 AK130514 AL050107 CAB43275 AL833852 CAD38711 BC014052 AAH14052 DA338432 DA760311 DA854089 DQ893378 ABM84304 DQ896699 ABM87698 XM_011512661 XP_011510963 NM_001168278 NP_001161750 NM_001168280 NP_001161752 NM_015472 NP_056287
Function Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.
Subcellular Location Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.
Tissue Specificity Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}.
Top Pathways Hippo signaling pathway

WW domain-containing transcription regulator protein 1 (WWTR1), Human, ELISA Kit - CSB-EL026170HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

WW domain containing transcription regulator 1, ELISA Kit - MBS922273 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 3.12 pg/ml.
Range 12.5 pg/ml -800 pg/ml.

WW Domain Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS2000050 from MyBioSource

Category ELISA Kit
Prices $410.00, $600.00, $810.00, $3,420.00, $6,200.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW domain-containing transcription regulator protein 1, ELISA Kit - MBS283394 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human WW domain-containing transcription regulator protein 1(WWTR1) ELISA kit - CSB-EL026170HU from Cusabio

Category ELISA Kit
Sensitivity 4.68 pg/ml.
Range 18.75 pg/ml-1200 pg/ml

Tafazzin (TAZ), Human, ELISA Kit - DL-TAZ-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.156-10 ng/mL

Human WWTR1 ELISA Kit - orb370910 from Biorbyt

Category ELISA Kit
Prices $595.00, $672.00
Sizes 48 test, 96 test

Human TAZ ELISA Kit - abx571689 from Abbexa

Category ELISA Kit
Sensitivity 0.054 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human WWTR1 ELISA Kit - abx576546 from Abbexa

Category ELISA Kit

Custom Human TAZ/WWTR1 ELISA - ELH-TAZ-1 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human TAZ/WWTR1 ELISA Kit - orb384874 from Biorbyt

Category ELISA Kit
Prices $1,411.00, $2,448.00, $5,321.00
Sizes 96 assays, 192 assays, 480 assays

Human TAZ ELISA Kit - E037424 from Biobool

Category ELISA Kit

Human WWTR1 ELISA Kit - E040699 from Biobool

Category ELISA Kit
Sensitivity 4.7 pg/ml

anti-TAZ antibody - ARG55020 from Arigo Biolaboratories

Category ELISA Kit

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393482 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393490 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393475 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393478 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393476 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393477 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393481 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393486 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393479 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393483 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

WW Domain-Containing Transcription Regulator Protein 1 (WWTR1), ELISA Kit - MBS9393485 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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