| Gene Symbol |
WWTR1
|
| Entrez Gene |
25937
|
| Alt Symbol |
TAZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WW domain containing transcription regulator 1
|
| Other Description |
WW domain-containing transcription regulator protein 1|transcriptional co-activator with PDZ-binding motif|transcriptional coactivator with PDZ-binding motif
|
| Swissprots |
Q9Y3W6 Q8N3P2 Q9GZV5 D3DNH7
|
| Accessions |
CAE90288 EAW78868 EAW78869 Q9GZV5 AJ299431 CAC17722 AK022036 BAB13957 AK025216 AK127620 AK130514 AL050107 CAB43275 AL833852 CAD38711 BC014052 AAH14052 DA338432 DA760311 DA854089 DQ893378 ABM84304 DQ896699 ABM87698 XM_011512661 XP_011510963 NM_001168278 NP_001161750 NM_001168280 NP_001161752 NM_015472 NP_056287
|
| Function |
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.
|
| Tissue Specificity |
Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}.
|
| Top Pathways |
Hippo signaling pathway
|