WWTR1

Gene Symbol	WWTR1
Entrez Gene	25937
Alt Symbol	TAZ
Species	Human
Gene Type	protein-coding
Description	WW domain containing transcription regulator 1
Other Description	WW domain-containing transcription regulator protein 1|transcriptional co-activator with PDZ-binding motif|transcriptional coactivator with PDZ-binding motif
Swissprots	Q9Y3W6 Q8N3P2 Q9GZV5 D3DNH7
Accessions	CAE90288 EAW78868 EAW78869 Q9GZV5 AJ299431 CAC17722 AK022036 BAB13957 AK025216 AK127620 AK130514 AL050107 CAB43275 AL833852 CAD38711 BC014052 AAH14052 DA338432 DA760311 DA854089 DQ893378 ABM84304 DQ896699 ABM87698 XM_011512661 XP_011510963 NM_001168278 NP_001161750 NM_001168280 NP_001161752 NM_015472 NP_056287
Function	Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.
Subcellular Location	Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.
Tissue Specificity	Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:19010321}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TAZ full length protein - ab153252 from Abcam Category Protein Source Wheat germ Species Human

Human TAZ full length protein - ab174421 from Abcam Category Protein Source E. coli Species Human

Human TAZ protein fragment - ab153253 from Abcam Category Protein Source Wheat germ Species Human

TAZ Antibody Blocking Peptide - LS-E25962 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TAZ Antibody Blocking Peptide - LS-E9789 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWTR1 / TAZ Antibody Blocking Peptide - LS-E4164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWTR1 / TAZ Blocking Peptide - LS-E11418 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TAZ/WWTR1 Protein - H00025937-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Tafazzin/TAZ Protein - H00006901-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TAZ/WWTR1 Partial Recombinant Protein - H00025937-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human TAZ/WWTR1 Protein - NBP2-22949 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

WWTR1-Antibody-C-term-Blocking-Peptide - BP16419b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WWTR1 protein (His tag) - 80R-3613 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

TAZ Blocking Peptide - abx063330 from Abbexa Category Peptide Species Human, Mouse, Rat

WWTR1 / TAZ (1-400, His-tag) - AR51300PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

WWTR1 / TAZ (1-400, His-tag) - AR51300PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

WWTR1 / TAZ - H00025937-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WWTR1 / TAZ - H00025937-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WWTR1 / TAZ - H00025937-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WWTR1 / TAZ - H00025937-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WWTR1, 1-400aa, Human, His tag, E.coli - 01-P2480 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

WWTR1,TAZ fusion protein - ag19659 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WWTR1,TAZ fusion protein - Ag13330 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human WW domain-containing transcription regulator protein 1(WWTR1) - CSB-YP887938HU CSB-EP887938HU CSB-BP887938HU CSB-MP887938HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WW Domain Containing Transcription Regulator 1 Protein (Recombinant) - abx261233 from Abbexa Category Protein

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