AFF4

Gene Symbol	AFF4
Entrez Gene	27125
Alt Symbol	AF5Q31, MCEF
Species	Human
Gene Type	protein-coding
Description	AF4/FMR2 family, member 4
Other Description	AF4/FMR2 family member 4|ALL1-fused gene from chromosome 5q31 protein|major CDK9 elongation factor-associated protein
Swissprots	Q59FB3 Q9UHB7 B2RP19 B7WPD2 Q6P592 Q8TDR1 Q498B2 Q9P0E4
Accessions	EAW62301 EAW62302 EAW62303 EAW62304 EAW62305 Q9UHB7 AA706988 AB209547 BAD92784 AF161355 AAF28915 AF173886 AAQ13633 AF197927 AAF18981 AF213987 AAM00184 AK024831 AK055638 AK126818 AK307407 BC025700 AAH25700 BC040454 BC063007 AAH63007 BC100287 AAI00288 BC137226 AAI37227 BC144538 BX537585 DA934874 XM_005271963 XP_005272020 XM_005271964 XP_005272021 XM_006714587 XP_006714650 NM_014423 NP_055238
Function	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12065898}. Note=Associates to transcriptionally active chromatin but not at snRNA genes. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain. {ECO:0000269|PubMed:10588740, ECO:0000269|PubMed:12065898}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AFF4 full length protein - ab162086 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human AFF4 protein fragment - ab162087 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

AF5Q31 / AFF4 Antibody Blocking Peptide - LS-E11118 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AF5Q31 / AFF4 Antibody Blocking Peptide - LS-E10263 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human AFF4 Protein - H00027125-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human AFF4 Protein - H00027125-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

AF5q31-Antibody-N-term-Blocking-Peptide - BP9688a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AFF4 / MCEF - H00027125-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AFF4 / MCEF - H00027125-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AFF4 / MCEF - H00027125-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

AFF4 / MCEF - H00027125-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

AFF4 fusion protein - Ag6476 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

AFF4 fusion protein - Ag3931 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

AFF4 fusion protein - Ag6336 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human AFF4, His-tagged - AFF4-9457H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human AFF4 - AFF4-696H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human AF4/FMR2 family member 4(AFF4) ,partial - CSB-YP890687HU CSB-EP890687HU CSB-BP890687HU CSB-MP890687HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

AF4/FMR2 family member 4(Aff4) ,partial - MBS1437456 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

AFF4 Recombinant Protein Antigen - NBP1-89220PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AFF4 Peptide, Human - M34GP00351H from Creative Peptides Category Peptide Source Synthetic. Species Human

AFF4 Recombinant Protein Antigen - NBP2-56715PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

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