AFF4

Gene Symbol	AFF4
Entrez Gene	27125
Alt Symbol	AF5Q31, MCEF
Species	Human
Gene Type	protein-coding
Description	AF4/FMR2 family, member 4
Other Description	AF4/FMR2 family member 4|ALL1-fused gene from chromosome 5q31 protein|major CDK9 elongation factor-associated protein
Swissprots	Q59FB3 Q9UHB7 B2RP19 B7WPD2 Q6P592 Q8TDR1 Q498B2 Q9P0E4
Accessions	EAW62301 EAW62302 EAW62303 EAW62304 EAW62305 Q9UHB7 AA706988 AB209547 BAD92784 AF161355 AAF28915 AF173886 AAQ13633 AF197927 AAF18981 AF213987 AAM00184 AK024831 AK055638 AK126818 AK307407 BC025700 AAH25700 BC040454 BC063007 AAH63007 BC100287 AAI00288 BC137226 AAI37227 BC144538 BX537585 DA934874 XM_005271963 XP_005272020 XM_005271964 XP_005272021 XM_006714587 XP_006714650 NM_014423 NP_055238
Function	Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12065898}. Note=Associates to transcriptionally active chromatin but not at snRNA genes. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain. {ECO:0000269|PubMed:10588740, ECO:0000269|PubMed:12065898}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AFF4 (G-1) - sc-390310 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

AFF4 (F-12) - sc-107133 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AFF4 (H-189) - sc-135337 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

AFF4 (N-14) - sc-107134 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

AFF4 (3D2) - sc-101062 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-AFF4 antibody - ab57077 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-AFF4 antibody - ab103586 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AFF4 antibody - ab75866 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AFF4 antibody - ab136340 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, APC) - LS-C232465 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, AP) - LS-C232466 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, Biotin) - LS-C232467 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, FITC) - LS-C232468 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30) - LS-C156127 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, PE) - LS-C232470 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1-30, Azide-free, HRP) - LS-C249385 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa50-100) - LS-C289268 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa1113-1163) - LS-C289269 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody - LS-C306122 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (aa751-800) - LS-C169503 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody - LS-C309346 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (clone 2E12) - LS-C105131 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E12

Anti-AF5Q31 / AFF4 Antibody (aa1-30) - LS-C319359 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-AF5Q31 / AFF4 Antibody (Internal) - LS-C345306 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

AFF4 Antibody (2E12) - H00027125-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2E12

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