AFF4

Gene Symbol AFF4
Entrez Gene 27125
Alt Symbol AF5Q31, MCEF
Species Human
Gene Type protein-coding
Description AF4/FMR2 family, member 4
Other Description AF4/FMR2 family member 4|ALL1-fused gene from chromosome 5q31 protein|major CDK9 elongation factor-associated protein
Swissprots Q59FB3 Q9UHB7 B2RP19 B7WPD2 Q6P592 Q8TDR1 Q498B2 Q9P0E4
Accessions EAW62301 EAW62302 EAW62303 EAW62304 EAW62305 Q9UHB7 AA706988 AB209547 BAD92784 AF161355 AAF28915 AF173886 AAQ13633 AF197927 AAF18981 AF213987 AAM00184 AK024831 AK055638 AK126818 AK307407 BC025700 AAH25700 BC040454 BC063007 AAH63007 BC100287 AAI00288 BC137226 AAI37227 BC144538 BX537585 DA934874 XM_005271963 XP_005272020 XM_005271964 XP_005272021 XM_006714587 XP_006714650 NM_014423 NP_055238
Function Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12065898}. Note=Associates to transcriptionally active chromatin but not at snRNA genes. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Strongly expressed in heart, placenta, skeletal muscle, pancreas and to a lower extent in brain. {ECO:0000269|PubMed:10588740, ECO:0000269|PubMed:12065898}.

AFF4 CRISPR/Cas9 KO Plasmid (h) - sc-406238 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 HDR Plasmid (h) - sc-406238-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 Double Nickase Plasmid (h) - sc-406238-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 Double Nickase Plasmid (h2) - sc-406238-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 CRISPR Activation Plasmid (h) - sc-406238-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 CRISPR Activation Plasmid (h2) - sc-406238-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 Lentiviral Activation Particles (h) - sc-406238-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 Lentiviral Activation Particles (h2) - sc-406238-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 siRNA (h) - sc-91842 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AFF4 shRNA Plasmid (h) - sc-91842-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AFF4 shRNA (h) Lentiviral Particles - sc-91842-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AFF4 RNAi - H00027125-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2919 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2919 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

AFF4 siRNA (Human) - CRH8979 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AFF4 - MBS8214825 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AFF4 CRISPR/Cas9 KO Plasmid (h2) - sc-406238-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFF4 HDR Plasmid (h2) - sc-406238-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human AFF4(NM_014423.3) - SHG031211 from Creative biogene

Category siRNA
Species Reactivities Human

Human AFF4 siRNA - orb269481 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AFF4 shRNA Plasmid (Human) - CHH8979 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AFF4 miRNA 3'UTR clone - MiUTR1H-00230 from Creative biogene

Species Reactivities Human
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