| Gene Symbol |
CALCRL
|
| Entrez Gene |
10203
|
| Alt Symbol |
CGRPR, CRLR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcitonin receptor-like
|
| Other Description |
CGRP type 1 receptor|calcitonin gene-related peptide type 1 receptor|calcitonin receptor-like receptor
|
| Swissprots |
A8K6G5 Q53TS5 Q16602 Q53S02 A8KAD3
|
| Accessions |
AAY14806 AAY14996 EAX10925 EAX10926 Q16602 AA436933 AA961493 AK291630 BAF84319 AK292998 BAF85687 AL602685 AY389506 AAQ91332 BC156827 AAI56828 BQ002778 CB270158 DA097876 DA215003 DA217003 DA883991 DQ280490 DQ280491 ABC16643 L76380 AAC41994 U17473 AAA62158 XM_005246231 XP_005246288 XM_005246232 XP_005246289 XM_005246234 XP_005246291 NM_001271751 NP_001258680 NM_005795 NP_005786
|
| Function |
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269|PubMed:22102369}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominantly expressed in the lung and heart.
|
| Top Pathways |
Vascular smooth muscle contraction, Neuroactive ligand-receptor interaction
|