Gene Symbol | CALCRL |
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Entrez Gene | 10203 |
Alt Symbol | CGRPR, CRLR |
Species | Human |
Gene Type | protein-coding |
Description | calcitonin receptor-like |
Other Description | CGRP type 1 receptor|calcitonin gene-related peptide type 1 receptor|calcitonin receptor-like receptor |
Swissprots | A8K6G5 Q53TS5 Q16602 Q53S02 A8KAD3 |
Accessions | AAY14806 AAY14996 EAX10925 EAX10926 Q16602 AA436933 AA961493 AK291630 BAF84319 AK292998 BAF85687 AL602685 AY389506 AAQ91332 BC156827 AAI56828 BQ002778 CB270158 DA097876 DA215003 DA217003 DA883991 DQ280490 DQ280491 ABC16643 L76380 AAC41994 U17473 AAA62158 XM_005246231 XP_005246288 XM_005246232 XP_005246289 XM_005246234 XP_005246291 NM_001271751 NP_001258680 NM_005795 NP_005786 |
Function | Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269|PubMed:22102369}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominantly expressed in the lung and heart. |
Top Pathways | Vascular smooth muscle contraction, Neuroactive ligand-receptor interaction |
CRLR peptide - ab183192 from Abcam
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Human CRLR full length protein - ab160875 from Abcam
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Human CRLR peptide - ab99160 from Abcam
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Human CRLR protein fragment - ab160876 from Abcam
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CALCRL / CGRP Receptor Antibody Blocking Peptide - LS-E5376 from LifeSpan Bioscience
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CALCRL / CGRP Receptor Antibody Blocking Peptide - LS-E29174 from LifeSpan Bioscience
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CALCRL / CGRP Receptor Antibody Blocking Peptide - LS-E29178 from LifeSpan Bioscience
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Recombinant Human CALCRL Protein - H00010203-Q01 from Novus Biologicals
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CALCRL Recombinant Protein - H00010203-P02 from Novus Biologicals
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Recombinant Human CALCRL Protein - H00010203-G01 from Novus Biologicals
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CALCRL-Antibody-Center-Blocking-Peptide - BP17873c from Abgent, a WuXi AppTec company
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CRLR peptide - orb72568 from Biorbyt
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CALCRL Blocking Peptide - 33R-1962 from Fitzgerald
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CGRP type 1 receptor / CRLR - H00010203-G01 from Acris Antibodies
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CGRP type 1 receptor / CRLR - H00010203-P02 from Acris Antibodies
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CGRP type 1 receptor / CRLR - H00010203-Q01-10 from Acris Antibodies
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CGRP type 1 receptor / CRLR - H00010203-Q01-25 from Acris Antibodies
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ChemiScreen™Human CGRP1 Calcitonin Receptor Membrane Preparation - HTS172M from EMD Millipore
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CALCRL Recombinant Protein Antigen - NBP1-85643PEP from Novus Biologicals
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CALCRL Peptide, Human - M34GP02296H from Creative Peptides
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CALCRL Recombinant Protein Antigen - NBP2-58137PEP from Novus Biologicals
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Calcitonin gene-related peptide type 1 receptor (CALCRL), Recombinant Protein - MBS7010720 from MyBioSource
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