Gene Symbol | CALCRL |
---|---|
Entrez Gene | 10203 |
Alt Symbol | CGRPR, CRLR |
Species | Human |
Gene Type | protein-coding |
Description | calcitonin receptor-like |
Other Description | CGRP type 1 receptor|calcitonin gene-related peptide type 1 receptor|calcitonin receptor-like receptor |
Swissprots | A8K6G5 Q53TS5 Q16602 Q53S02 A8KAD3 |
Accessions | AAY14806 AAY14996 EAX10925 EAX10926 Q16602 AA436933 AA961493 AK291630 BAF84319 AK292998 BAF85687 AL602685 AY389506 AAQ91332 BC156827 AAI56828 BQ002778 CB270158 DA097876 DA215003 DA217003 DA883991 DQ280490 DQ280491 ABC16643 L76380 AAC41994 U17473 AAA62158 XM_005246231 XP_005246288 XM_005246232 XP_005246289 XM_005246234 XP_005246291 NM_001271751 NP_001258680 NM_005795 NP_005786 |
Function | Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269|PubMed:22102369}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominantly expressed in the lung and heart. |
Top Pathways | Vascular smooth muscle contraction, Neuroactive ligand-receptor interaction |
CRLR CRISPR/Cas9 KO Plasmid (h) - sc-401631 from Santa Cruz Biotechnology
|
||||||||
CRLR HDR Plasmid (h) - sc-401631-HDR from Santa Cruz Biotechnology
|
||||||||
CRLR Double Nickase Plasmid (h) - sc-401631-NIC from Santa Cruz Biotechnology
|
||||||||
CRLR Double Nickase Plasmid (h2) - sc-401631-NIC-2 from Santa Cruz Biotechnology
|
||||||||
CRLR CRISPR Activation Plasmid (h) - sc-401631-ACT from Santa Cruz Biotechnology
|
||||||||
CRLR CRISPR Activation Plasmid (h2) - sc-401631-ACT-2 from Santa Cruz Biotechnology
|
||||||||
CRLR Lentiviral Activation Particles (h) - sc-401631-LAC from Santa Cruz Biotechnology
|
||||||||
CRLR Lentiviral Activation Particles (h2) - sc-401631-LAC-2 from Santa Cruz Biotechnology
|
||||||||
CRLR siRNA (h) - sc-43705 from Santa Cruz Biotechnology
|
||||||||
CRLR shRNA Plasmid (h) - sc-43705-SH from Santa Cruz Biotechnology
|
||||||||
CRLR shRNA (h) Lentiviral Particles - sc-43705-V from Santa Cruz Biotechnology
|
||||||||
CALCRL RNAi - H00010203-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU003121 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5295 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5295 from Sigma-Aldrich
|
||||||||
CALCRL siRNA (Human) - CRH6892 from Cohesion Biosciences
|
||||||||
CALCRL - MBS8227164 from MyBioSource
|
||||||||
shRNA set against Human CALCRL (NM_005795.4) - SHH253749 from Creative biogene
|
||||||||
shRNA set against Human CALCRL(NM_005795.4) - SHG137161 from Creative biogene
|
||||||||
CALCRL shRNA Plasmid (Human) - CHH6892 from Cohesion Biosciences
|
||||||||
CALCRL miRNA 3'UTR clone - MiUTR1H-01625 from Creative biogene
|