CDC42BPB

Gene Symbol CDC42BPB
Entrez Gene 9578
Alt Symbol MRCKB
Species Human
Gene Type protein-coding
Description CDC42 binding protein kinase beta (DMPK-like)
Other Description CDC42-binding protein kinase beta (DMPK-like)|CDC42BP-beta|DMPK-like beta|MRCK beta|myotonic dystrophy kinase-related CDC42-binding kinase beta|myotonic dystrophy protein kinase-like beta|serine/threonine-protein kinase MRCK beta
Swissprots Q2L7A5 Q9ULU5 A9JR72 Q9Y5S2 Q86TJ1
Accessions ABC67469 EAW81800 EAW81801 Q9Y5S2 AB032950 BAA86438 AF128625 AAD37506 AK094920 AK126684 BC047871 AAH47871 BC048261 AAH48261 BC155541 AAI55542 BC156936 AAI56937 BX248752 CAD66559 BX647753 XM_005268227 XP_005268284 XM_005268228 XP_005268285 XM_005268229 XP_005268286 XM_005268230 XP_005268287 XM_011537387 XP_011535689 XR_943564 NM_006035 NP_006026
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. {ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187}; Peripheral membrane protein {ECO:0000269|PubMed:21240187}; Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. {ECO:0000250}.
Tissue Specificity Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.

MRCKβ (C-19) - sc-15299 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MRCKβ (C-19): sc-15299. Western blot analysis of MRCKβ expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.

MRCKβ (H-125) - sc-48834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MRCKβ (H-125): sc-48834. Immunofluorescence staining of normal mouse intestine frozen section showing membrane staining.

MRCKβ (Y-2D13) - sc-134392 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MRCKβ (Y-2D13): sc-134392. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing cytoplasmic localization.

Anti-CDC42 Binding Protein Kinase Beta antibody - ab61328 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-CDC42 Binding Protein Kinase Beta antibody (ab61328) at 1 µg/ml + Jurkat whole cell lysate at 50 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-CDC42 Binding Protein Kinase Beta antibody - ab69589 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human brain tissue using ab69589 at 1/50-1/100 dilution. Right hand panel was treated with immunising peptide.

Anti-CDC42 Binding Protein Kinase Beta antibody - ab56782 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56782 CDC42 Binding Protein Kinase Beta antibody at 1ug/ml.

Anti-CDC42 Binding Protein Kinase Beta antibody - C-terminal - ab201178 from Abcam

Prices $359.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human placenta tissue labeling CDC42 Binding Protein Kinase Beta with ab201178 at 1/100.

Anti-CDC42BPB / MRCKB Antibody (Phe1665) IHC-plus™ - LS-B11752 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CDC42BPB / MRCKB Antibody (clone 6G3) - LS-C105085 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G3
CDC42BPB monoclonal antibody (M02), clone 6G3 Western blot of CDC42BPB expression in HeLa.

Anti-CDC42BPB / MRCKB Antibody (clone 2F4) - LS-C133593 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Immunoperoxidase of monoclonal antibody to CDC42BPB on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

Anti-CDC42BPB / MRCKB Antibody (aa1641-1690) IHC-plus™ - LS-B8531 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CDC42BPB antibody IHC of human lung, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8531 dilution 5 ug/ml.

Anti-CDC42BPB / MRCKB Antibody (aa941-990) - LS-C151975 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CDC42BPB / MRCKB antibody Western Blot of MCF7.

CDC42BPB Antibody (2F4) - H00009578-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Western Blot: CDC42BPB Antibody (2F4) [H00009578-M03] - Analysis of CDC42BPB expression in PC-12 (Cat # L012V1).

CDC42BPB Antibody - NBP1-81440 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CDC42BPB Antibody [NBP1-81440] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

CDC42BPB Antibody (6G3) - H00009578-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G3
Western Blot: CDC42BPB Antibody (6G3) [H00009578-M02] - CDC42BPB monoclonal antibody (M02), clone 6G3 Analysis of CDC42BPB expression in HeLa.

CDC42BPB Antibody (2D8) - H00009578-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D8
Western Blot: CDC42BPB Antibody (2D8) [H00009578-M04] - Analysis of CDC42BPB expression in Raw 264.7 (Cat # L024V1).

CDC42BPB Antibody (5F12) - H00009578-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F12
Immunocytochemistry/Immunofluorescence: CDC42BPB Antibody (5F12) [H00009578-M01] - Analysis of monoclonal antibody to CDC42BPB on HeLa cell. Antibody concentration 10 ug/ml.

CDC42BPB Antibody - H00009578-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Monoclonal Anti-CDC42BPB antibody produced in mouse - SAB1410014 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D8
<B>Immunoblotting</B><BR/>Monoclonal Anti-CDC42BPB: <B>Cat. No. SAB1410014</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~194.4 kDa using Jurkat lysate.

Monoclonal Anti-CDC42BPB antibody produced in mouse - SAB1410013 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G3
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-CDC42BPB: <B>Cat. No. SAB1410013</B>: Antibody concentration: 3 μg/mL using human testis tissue.

Anti-MRCKB, C-Terminal antibody produced in rabbit - SAB4503673 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MRCKB, C-Terminal: <B>Cat. No. SAB4503673</B>: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-MRCKB, C-Terminal antibody. Cells on the left were treated with the Anti-MRCKB, C-Terminal antibody. Cells on the right (negative control) were treated with both Anti-MRCKB, C-Terminal antibody and the synthesized immunogen peptide.

Anti-CDC42BPB antibody produced in rabbit - HPA022821 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AL117209.2: <B>Cat. No. HPA022821</B>: Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in decidual cells.

Monoclonal Anti-CDC42BPB antibody produced in mouse - WH0009578M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F12
<B>Immunoblotting</B><BR/>Monoclonal Anti-CDC42BPB, <B>Cat. No. WH0009578M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37 kDa using immunogen protein lysate.

Anti-CDC42BPB (861-873) antibody produced in rabbit - C3495 from Sigma-Aldrich

Prices $342.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CDC42BPB (861-873) (RB): <B>Cat. No. C3495</B>: Immunofluorescence of HUVEC cells using CDC42BPB (861-873) (RB), <B>Cat. No. C3495</B> (red) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used.<BR/>Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Monoclonal Anti-CDC42BPB antibody produced in mouse - SAB1404739 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-CDC42BPB: <B>Cat. No. SAB1404739</B>: Antibody concentration: 3 μg/mL using human small Intestine tissue.
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