CDC42BPB

Gene Symbol CDC42BPB
Entrez Gene 9578
Alt Symbol MRCKB
Species Human
Gene Type protein-coding
Description CDC42 binding protein kinase beta (DMPK-like)
Other Description CDC42-binding protein kinase beta (DMPK-like)|CDC42BP-beta|DMPK-like beta|MRCK beta|myotonic dystrophy kinase-related CDC42-binding kinase beta|myotonic dystrophy protein kinase-like beta|serine/threonine-protein kinase MRCK beta
Swissprots Q2L7A5 Q9ULU5 A9JR72 Q9Y5S2 Q86TJ1
Accessions ABC67469 EAW81800 EAW81801 Q9Y5S2 AB032950 BAA86438 AF128625 AAD37506 AK094920 AK126684 BC047871 AAH47871 BC048261 AAH48261 BC155541 AAI55542 BC156936 AAI56937 BX248752 CAD66559 BX647753 XM_005268227 XP_005268284 XM_005268228 XP_005268285 XM_005268229 XP_005268286 XM_005268230 XP_005268287 XM_011537387 XP_011535689 XR_943564 NM_006035 NP_006026
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. {ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187}; Peripheral membrane protein {ECO:0000269|PubMed:21240187}; Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. {ECO:0000250}.
Tissue Specificity Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.

MRCKβ siRNA (h) - sc-60064 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRCKβ shRNA Plasmid (h) - sc-60064-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRCKβ shRNA (h) Lentiviral Particles - sc-60064-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CDC42BPB RNAi - H00009578-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU101431 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU100681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0326 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0327 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0328 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN5784 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5784 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CDC42BPB siRNA (Human) - CRH6373 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CDC42BPB - MBS8208013 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CDC42BPB (NM_006035.3) - SHH259833 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CDC42BPB(NM_006035.3) - SHG161569 from Creative biogene

Category siRNA
Species Reactivities Human

Human CDC42BPB siRNA - orb266875 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CDC42BPB shRNA Plasmid (Human) - CHH6373 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CDC42BPB miRNA 3'UTR clone - MiUTR1H-01957 from Creative biogene

Species Reactivities Human
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