| Gene Symbol |
CDC42BPB
|
| Entrez Gene |
9578
|
| Alt Symbol |
MRCKB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC42 binding protein kinase beta (DMPK-like)
|
| Other Description |
CDC42-binding protein kinase beta (DMPK-like)|CDC42BP-beta|DMPK-like beta|MRCK beta|myotonic dystrophy kinase-related CDC42-binding kinase beta|myotonic dystrophy protein kinase-like beta|serine/threonine-protein kinase MRCK beta
|
| Swissprots |
Q2L7A5 Q9ULU5 A9JR72 Q9Y5S2 Q86TJ1
|
| Accessions |
ABC67469 EAW81800 EAW81801 Q9Y5S2 AB032950 BAA86438 AF128625 AAD37506 AK094920 AK126684 BC047871 AAH47871 BC048261 AAH48261 BC155541 AAI55542 BC156936 AAI56937 BX248752 CAD66559 BX647753 XM_005268227 XP_005268284 XM_005268228 XP_005268285 XM_005268229 XP_005268286 XM_005268230 XP_005268287 XM_011537387 XP_011535689 XR_943564 NM_006035 NP_006026
|
| Function |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. {ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187}; Peripheral membrane protein {ECO:0000269|PubMed:21240187}; Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.
|