CDC42BPB

Gene Symbol	CDC42BPB
Entrez Gene	9578
Alt Symbol	MRCKB
Species	Human
Gene Type	protein-coding
Description	CDC42 binding protein kinase beta (DMPK-like)
Other Description	CDC42-binding protein kinase beta (DMPK-like)|CDC42BP-beta|DMPK-like beta|MRCK beta|myotonic dystrophy kinase-related CDC42-binding kinase beta|myotonic dystrophy protein kinase-like beta|serine/threonine-protein kinase MRCK beta
Swissprots	Q2L7A5 Q9ULU5 A9JR72 Q9Y5S2 Q86TJ1
Accessions	ABC67469 EAW81800 EAW81801 Q9Y5S2 AB032950 BAA86438 AF128625 AAD37506 AK094920 AK126684 BC047871 AAH47871 BC048261 AAH48261 BC155541 AAI55542 BC156936 AAI56937 BX248752 CAD66559 BX647753 XM_005268227 XP_005268284 XM_005268228 XP_005268285 XM_005268229 XP_005268286 XM_005268230 XP_005268287 XM_011537387 XP_011535689 XR_943564 NM_006035 NP_006026
Function	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. {ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949762}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:21240187}; Peripheral membrane protein {ECO:0000269|PubMed:21240187}; Cytoplasmic side {ECO:0000269|PubMed:21240187}. Cell junction {ECO:0000269|PubMed:21240187}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42. {ECO:0000250}.
Tissue Specificity	Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. {ECO:0000269|PubMed:10198171}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDC42 Binding Protein Kinase Beta protein fragment - ab56638 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human CDC42 Binding Protein Kinase Beta protein fragment - ab160556 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDC42BPB / MRCKB Antibody Blocking Peptide - LS-E23820 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDC42BPB Partial Recombinant Protein - H00009578-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CDC42BPB Protein - P4262 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

CDC42BPB Recombinant Protein - P4638 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant CDC42BPB Protein - NBP1-99505 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Human CDC42BPB His GST tag protein - orb84494 from Biorbyt Category Protein Prices $417.00, $570.00 Sizes 20 μg, 50 μg Source Insect Species Human

CDC42BPB - H00009578-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDC42BPB - H00009578-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDC42BPB - P4262 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

CDC42BPB - P4638 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

CDC42BPB - P5731 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Recombinant Human CDC42 Binding Protein Kinase Beta, GST-His-tagged - CDC42BPB-369H from Creative Biomart Category Protein Source Sf9 cells Species Human

Recombinant Human CDC42BPB, GST-tagged, Active - CDC42BPB-358H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human CDC42BPB, His & GST tagged - CDC42BPB-2501H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

CDC42BPB - PN201384 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Baculovirus Species Human

MRCKβ Protein, active, 250 µg - 14-643M from EMD Millipore Category Protein Prices $2,441.00 Sizes 250 µg also available in 10 μg size . (cat#14-643) and in bulk (cat#14-643-K) Source human MRCKb amino acids 1-473, expressed by baculovirus in Sf21 cells

MRCKβ (F1665) Peptide - BS2382P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Active MRCK beta - 7772-5 from Biovision Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Recombinant Human CDC42BPB GST-His Active - CRC025A from Cell Science Prices $585.00 Sizes 10 μg Species Human

Recombinant Human CDC42BPB Protein (His & GST tag) - PKSH031097 from Elabscience Category Protein Source Baculovirus-Insect Cells Species Human

CDC42BPB Recombinant Protein Antigen - NBP1-81440PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MRCKβ Protein, active, 10 µg - 14-643 from EMD Millipore Category Protein Prices $308.00 Sizes 10 µg Source human MRCKb amino acids 1-473, expressed by baculovirus in Sf21 cells

CDC42BPB Peptide, Human - M34GP02807H from Creative Peptides Category Peptide Source Synthetic. Species Human

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