| Gene Symbol |
DBF4B
|
| Entrez Gene |
80174
|
| Alt Symbol |
ASKL1, CHIFB, DRF1, ZDBF1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DBF4 zinc finger B
|
| Other Description |
ASK-like protein 1|DBF4 homolog B|Dbf4-related factor 1|activator of S-phase kinase-like protein 1|chiffon homolog B|protein DBF4 homolog B|zinc finger, DBF-type containing 1B
|
| Swissprots |
Q96B19 Q9H912 Q8NFT6 Q8TEX0 D3DX56
|
| Accessions |
EAW51581 EAW51582 EAW51583 EAW51584 EAW51585 EAW51586 EAW51587 Q8NFT6 AF448801 AAM73808 AF465820 AAL75985 AK023149 BAB14431 AK125771 BAG54245 AK295296 BAG58278 AK303282 BAG64361 AW290902 AY358101 AAQ88468 BC016158 AAH16158 BC026999 BC033660 BM476186 DA475446 XM_006722098 XP_006722161 XM_006722099 XP_006722162 XM_006722100 XP_006722163 XM_006722101 XP_006722164 XM_006722102 XP_006722165 XM_006722104 XP_006722167 XM_006722105 XP_006722168 XM_006722106 XP_006722169 XM_011525277 XP_011523579 XM_011525278 XP_011523580 XM_011525279 XP_011523581 XM_011525280 XP_011523582 XM_011525281 XP_011523583 XM_011525282 XP_011523584 XM_011525283 XP_011523585 XM_011525284 XP_011523586 NM_025104 NP_079380 NM_145663 NP_663696 NR_036623
|
| Function |
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232, ECO:0000269|PubMed:17062569}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232}. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
|
| Tissue Specificity |
Widely expressed. Highly expressed in testis. {ECO:0000269|PubMed:12065429}.
|