| Gene Symbol |
ZNF281
|
| Entrez Gene |
23528
|
| Alt Symbol |
ZBP-99, ZNP-99
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 281
|
| Other Description |
GC-box-binding zinc finger protein 1|ZNP-99 transcription factor|transcription factor ZBP-99|zinc finger DNA-binding protein 99
|
| Swissprots |
Q5RKW5 Q9Y2X9 Q9NY92 A6NF48 B3KMX2
|
| Accessions |
CAH05622 EAW91313 Q9Y2X9 AF086540 AF125158 AAD21084 AJ132591 CAB70967 AJ132592 CAB70968 AK021707 AK022916 BAG51134 AK022921 BAG51136 AK027284 BAG51299 AK094701 AK297233 BAG59716 BC016000 BC051905 AAH51905 BC060820 AAH60820 BG611294 BP216938 BQ012001 BQ013454 DB150929 NM_001281293 NP_001268222 NM_001281294 NP_001268223 NM_012482 NP_036614
|
| Function |
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10448078}.
|