Gene Symbol | ZNF281 |
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Entrez Gene | 23528 |
Alt Symbol | ZBP-99, ZNP-99 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein 281 |
Other Description | GC-box-binding zinc finger protein 1|ZNP-99 transcription factor|transcription factor ZBP-99|zinc finger DNA-binding protein 99 |
Swissprots | Q5RKW5 Q9Y2X9 Q9NY92 A6NF48 B3KMX2 |
Accessions | CAH05622 EAW91313 Q9Y2X9 AF086540 AF125158 AAD21084 AJ132591 CAB70967 AJ132592 CAB70968 AK021707 AK022916 BAG51134 AK022921 BAG51136 AK027284 BAG51299 AK094701 AK297233 BAG59716 BC016000 BC051905 AAH51905 BC060820 AAH60820 BG611294 BP216938 BQ012001 BQ013454 DB150929 NM_001281293 NP_001268222 NM_001281294 NP_001268223 NM_012482 NP_036614 |
Function | Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269|PubMed:10448078, ECO:0000269|PubMed:12771217}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10448078}. |
Human Zfp281 full length protein - ab153233 from Abcam
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Human Zfp281 protein fragment - ab153234 from Abcam
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ZNF281 / Zfp281 Antibody Blocking Peptide - LS-E31094 from LifeSpan Bioscience
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ZNF281 / Zfp281 Antibody Blocking Peptide - LS-E14064 from LifeSpan Bioscience
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ZNF281 Partial Recombinant Protein - H00023528-Q01 from Novus Biologicals
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Recombinant Human ZNF281 Protein - H00023528-P01 from Novus Biologicals
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ZNF281 Blocking Peptide - NBP1-76551PEP from Novus Biologicals
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ZNF281 - H00023528-P01 from Acris Antibodies
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ZNF281 - H00023528-Q01-10 from Acris Antibodies
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ZNF281 - H00023528-Q01-25 from Acris Antibodies
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ZNF281 control peptide - AP26119CP-N from Acris Antibodies
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ZFP281 Peptide - 6233P from ProSci
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Recombinant Human Zinc finger protein 281(ZNF281) ,partial - CSB-YP026637HU CSB-EP026637HU CSB-BP026637HU CSB-MP026637HU from Cusabio
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Zinc finger protein 281(ZNF281) ,partial, Recombinant Protein - MBS1373260 from MyBioSource
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ZNF281 Protein - NBP2-13564PEP from Novus Biologicals
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ZNF281-Antibody-Center-Blocking-Peptide - BP1983c from Abgent, a WuXi AppTec company
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ZNF281-Antibody-N-term-Blocking-Peptide - BP1983a from Abgent, a WuXi AppTec company
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ZNF281-Blocking-Peptide-Center - BP21118a from Abgent, a WuXi AppTec company
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ZNF281 Peptide, Human - M34GP17967H from Creative Peptides
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