DCP2

Gene Symbol DCP2
Entrez Gene 167227
Alt Symbol NUDT20
Species Human
Gene Type protein-coding
Description decapping mRNA 2
Other Description DCP2 decapping enzyme homolog|hDpc|m7GpppN-mRNA hydrolase|mRNA-decapping enzyme 2|nudix (nucleoside diphosphate linked moiety X)-type motif 20
Swissprots Q6P2D4 C9J778 Q7Z5W5 Q8IU60 Q8NBG5
Accessions EAW48988 EAW48989 EAW48990 EAW48991 EAW48992 Q8IU60 AA837315 AB002445 AK025019 AK090564 BAC03479 AK296361 BAH12331 AK311298 AL135390 AY135173 AAN08884 AY146650 AAN62762 BC017965 BC045596 AAH45596 BC064593 AAH64593 BC068042 BG720562 BX537716 BX648838 CF994730 DB146225 HQ448087 ADQ32568 XM_005271914 XP_005271971 NM_001242377 NP_001229306 NM_152624 NP_689837 NR_038352
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. {ECO:0000269|PubMed:12218187, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21070968}.
Subcellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
Tissue Specificity Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269|PubMed:21070968}.
Top Pathways RNA degradation

hDcp2 CRISPR/Cas9 KO Plasmid (h) - sc-418511 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 HDR Plasmid (h) - sc-418511-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 Double Nickase Plasmid (h) - sc-418511-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 Double Nickase Plasmid (h2) - sc-418511-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 CRISPR Activation Plasmid (h) - sc-418511-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 CRISPR Activation Plasmid (h2) - sc-418511-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 Lentiviral Activation Particles (h) - sc-418511-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 Lentiviral Activation Particles (h2) - sc-418511-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

hDcp2 siRNA (h) - sc-44388 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

hDcp2 shRNA Plasmid (h) - sc-44388-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

hDcp2 shRNA (h) Lentiviral Particles - sc-44388-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DCP2 RNAi - H00167227-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU142731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6997 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6997 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DCP2 siRNA (Human) - CRJ6056 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DCP2 - MBS8239667 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DCP2 (NM_152624.5) - SHH275277 from Creative biogene

Category siRNA
Species Reactivities Human

DCP2 shRNA Plasmid (Human) - CHJ6056 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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